IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.

Original languageEnglish
Pages (from-to)4213-4219
Number of pages7
JournalJournal of Immunology
Issue number9
StatePublished - Nov 1 2012


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