TY - JOUR
T1 - IL-4 in the brain
T2 - A cytokine to remember
AU - Gadani, Sachin P.
AU - Cronk, James C.
AU - Norris, Geoffrey T.
AU - Kipnis, Jonathan
PY - 2012/11/1
Y1 - 2012/11/1
N2 - IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.
AB - IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.
UR - http://www.scopus.com/inward/record.url?scp=84867916370&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1202246
DO - 10.4049/jimmunol.1202246
M3 - Short survey
C2 - 23087426
AN - SCOPUS:84867916370
SN - 0022-1767
VL - 189
SP - 4213
EP - 4219
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -