IL-4 in the brain: A cytokine to remember

Sachin P. Gadani, James C. Cronk, Geoffrey T. Norris, Jonathan Kipnis

Research output: Contribution to journalShort surveypeer-review

279 Scopus citations

Abstract

IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.

Original languageEnglish
Pages (from-to)4213-4219
Number of pages7
JournalJournal of Immunology
Volume189
Issue number9
DOIs
StatePublished - Nov 1 2012

Fingerprint

Dive into the research topics of 'IL-4 in the brain: A cytokine to remember'. Together they form a unique fingerprint.

Cite this