IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing

Gregory D. Rak, Lisa C. Osborne, Mark C. Siracusa, Brian S. Kim, Kelvin Wang, Ardeshir Bayat, David Artis, Susan W. Volk

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Breaches in the skin barrier initiate an inflammatory immune response that is critical for successful wound healing. Innate lymphoid cells (ILCs) are a recently identified population of immune cells that reside at epithelial barrier surfaces such as the skin, lung, and gut, and promote proinflammatory or epithelial repair functions after exposure to allergens, pathogens, or chemical irritants. However, the potential role of ILCs in regulating cutaneous wound healing remains undefined. Here, we demonstrate that cutaneous injury promotes an IL-33-dependent group 2 ILC (ILC2) response and that abrogation of this response impairs re-epithelialization and efficient wound closure. In addition, we provide evidence suggesting that an analogous ILC2 response is operational in acute wounds of human skin. Together, these results indicate that IL-33-responsive ILC2s are an important link between the cutaneous epithelium and the immune system, acting to promote the restoration of skin integrity after injury.

Original languageEnglish
Pages (from-to)487-496
Number of pages10
JournalJournal of Investigative Dermatology
Volume136
Issue number2
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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  • Cite this

    Rak, G. D., Osborne, L. C., Siracusa, M. C., Kim, B. S., Wang, K., Bayat, A., Artis, D., & Volk, S. W. (2016). IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing. Journal of Investigative Dermatology, 136(2), 487-496. https://doi.org/10.1038/JID.2015.406