IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation

Anthony R. French; Erika B. Holroyd; Liping Yang; Sungjin Kim; Wayne M. Yokoyama

doi:10.1016/j.cyto.2006.08.006

IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation

Anthony R. French, Erika B. Holroyd, Liping Yang, Sungjin Kim, Wayne M. Yokoyama

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Mature natural killer (NK) cells are able to vigorously proliferate in response to infectious stimuli such as viral infections. The factors driving NK cell proliferation under these circumstances are only beginning to be characterized. NK cells constitutively express interleukin-18 receptor α and are stimulated by IL-18 to produce IFNγ. Although IL-18 alone is not sufficient to drive NK cell proliferation, we demonstrate that IL-18 is able to act synergistically with IL-15 in stimulating in vitro NK cell proliferation. Furthermore using a NK cell line, we show that this effect occurs through direct stimulation of NK cells by IL-18 rather than through a secondary signal generated by an intermediary cell type. This raises the possibility that IL-18 may act synergistically with IL-15 in driving pathogen-induced NK cell proliferation in addition to its contribution in enhancing IL-12 stimulation of NK cell IFNγ production.

Original language	English
Pages (from-to)	229-234
Number of pages	6
Journal	Cytokine
Volume	35
Issue number	5-6
DOIs	https://doi.org/10.1016/j.cyto.2006.08.006
State	Published - Sep 2006

Keywords

IL-15
IL-18
NK cells
Proliferation

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10.1016/j.cyto.2006.08.006

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title = "IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation",

abstract = "Mature natural killer (NK) cells are able to vigorously proliferate in response to infectious stimuli such as viral infections. The factors driving NK cell proliferation under these circumstances are only beginning to be characterized. NK cells constitutively express interleukin-18 receptor α and are stimulated by IL-18 to produce IFNγ. Although IL-18 alone is not sufficient to drive NK cell proliferation, we demonstrate that IL-18 is able to act synergistically with IL-15 in stimulating in vitro NK cell proliferation. Furthermore using a NK cell line, we show that this effect occurs through direct stimulation of NK cells by IL-18 rather than through a secondary signal generated by an intermediary cell type. This raises the possibility that IL-18 may act synergistically with IL-15 in driving pathogen-induced NK cell proliferation in addition to its contribution in enhancing IL-12 stimulation of NK cell IFNγ production.",

keywords = "IL-15, IL-18, NK cells, Proliferation",

author = "French, {Anthony R.} and Holroyd, {Erika B.} and Liping Yang and Sungjin Kim and Yokoyama, {Wayne M.}",

note = "Funding Information: This work was supported by a K08 grant from the NIAID and a HHMI Faculty Development Award to A.R.F., the Barnes-Jewish Hospital Research Foundation, and NIH grants to W.M.Y. who is a HHMI investigator.",

year = "2006",

month = sep,

doi = "10.1016/j.cyto.2006.08.006",

language = "English",

volume = "35",

pages = "229--234",

journal = "Cytokine",

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T1 - IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation

AU - French, Anthony R.

AU - Holroyd, Erika B.

AU - Yang, Liping

AU - Kim, Sungjin

AU - Yokoyama, Wayne M.

N1 - Funding Information: This work was supported by a K08 grant from the NIAID and a HHMI Faculty Development Award to A.R.F., the Barnes-Jewish Hospital Research Foundation, and NIH grants to W.M.Y. who is a HHMI investigator.

PY - 2006/9

Y1 - 2006/9

N2 - Mature natural killer (NK) cells are able to vigorously proliferate in response to infectious stimuli such as viral infections. The factors driving NK cell proliferation under these circumstances are only beginning to be characterized. NK cells constitutively express interleukin-18 receptor α and are stimulated by IL-18 to produce IFNγ. Although IL-18 alone is not sufficient to drive NK cell proliferation, we demonstrate that IL-18 is able to act synergistically with IL-15 in stimulating in vitro NK cell proliferation. Furthermore using a NK cell line, we show that this effect occurs through direct stimulation of NK cells by IL-18 rather than through a secondary signal generated by an intermediary cell type. This raises the possibility that IL-18 may act synergistically with IL-15 in driving pathogen-induced NK cell proliferation in addition to its contribution in enhancing IL-12 stimulation of NK cell IFNγ production.

AB - Mature natural killer (NK) cells are able to vigorously proliferate in response to infectious stimuli such as viral infections. The factors driving NK cell proliferation under these circumstances are only beginning to be characterized. NK cells constitutively express interleukin-18 receptor α and are stimulated by IL-18 to produce IFNγ. Although IL-18 alone is not sufficient to drive NK cell proliferation, we demonstrate that IL-18 is able to act synergistically with IL-15 in stimulating in vitro NK cell proliferation. Furthermore using a NK cell line, we show that this effect occurs through direct stimulation of NK cells by IL-18 rather than through a secondary signal generated by an intermediary cell type. This raises the possibility that IL-18 may act synergistically with IL-15 in driving pathogen-induced NK cell proliferation in addition to its contribution in enhancing IL-12 stimulation of NK cell IFNγ production.

KW - IL-15

KW - IL-18

KW - NK cells

KW - Proliferation

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U2 - 10.1016/j.cyto.2006.08.006

DO - 10.1016/j.cyto.2006.08.006

M3 - Article

C2 - 17052916

AN - SCOPUS:35649022329

SN - 1043-4666

VL - 35

SP - 229

EP - 234

JO - Cytokine

JF - Cytokine

IS - 5-6

ER -

IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation

Abstract

Keywords

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