IL-17 in protective immunity to intracellular pathogens

Shabaana A. Khader, Radha Gopal

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

The identification of a new T-cell subset referred to as T helper 17 (Th17) cells and its role in protective immunity against extracellular bacterial infections is well established. In contrast, initial studies suggested that the IL-23-IL-17 pathway was not required for protection against intracellular pathogens such as mycobacterial infections. However, recent studies demonstrate that Th17-IL-23 pathway may play a crucial role in protective immunity against other intracellular pathogens by regulating the innate and adaptive immune responses. The current outlook on the role of IL-23-IL-17 pathway in protective immunity to intracellular pathogens is discussed here.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalVirulence
Volume1
Issue number5
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Keywords

  • IL-17
  • Intracellular pathogens
  • Th1
  • Th17

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