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IL-12, but not IFN-α, promotes STAT4 activation and Th1 development in murine CD4
+
T cells expressing a chimeric murine/human Stat2 gene
Meredith E. Persky
,
Kenneth M. Murphy
, J. David Farrar
Division of Immunobiology
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Institute of Clinical and Translational Sciences (ICTS)
Siteman Cancer Center
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Rheumatic Diseases Research Resource-Based Center
DBBS - Molecular Cell Biology
DBBS - Developmental, Regenerative and Stem Cell Biology
DBBS - Immunology
Research output
:
Contribution to journal
›
Article
›
peer-review
30
Scopus citations
Overview
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Dive into the research topics of 'IL-12, but not IFN-α, promotes STAT4 activation and Th1 development in murine CD4
+
T cells expressing a chimeric murine/human Stat2 gene'. Together they form a unique fingerprint.
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Keyphrases
Interleukin-12 (IL-12)
100%
CD4+ T Cells
100%
STAT4
100%
STAT2
100%
T Cells
37%
Knock-in Mouse Model
25%
CD4+
25%
C-terminus
25%
IFNAR1
25%
Phosphorylation
12%
Human Disease
12%
Cell Development
12%
Disease States
12%
Human Cells
12%
Cell Response
12%
CD4+ T
12%
CD8+ T Cells
12%
Interleukin-18 (IL-18)
12%
Specific mutation
12%
IFN Signaling
12%
Th1 Cells
12%
Targeting Strategies
12%
Murine Embryonic Stem Cells
12%
Immunology and Microbiology
T-Helper Cell
100%
STAT4
100%
T Cell
75%
STAT2
75%
Carboxy Terminal Sequence
50%
Secretion (Process)
25%
Cell Maturation
25%
CD4
25%
Cytotoxic T-Cell
25%
Interleukin 18
25%
Murine
25%
Human Cell
25%
Embryonic Stem Cell
25%
Breed
25%
Th1 Cell
25%