IL-10 restrains il-17 to limit lung pathology characteristics following pulmonary infection with francisella tularensis live vaccine strain

Samantha R. Slight, Leticia Monin, Radha Gopal, Lyndsay Avery, Marci Davis, Hillary Cleveland, Tim D. Oury, Javier Rangel-Moreno, Shabaana A. Khader

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

IL-10 production during intracellular bacterial infections is generally thought to be detrimental because of its role in suppressing protective T-helper cell 1 (Th1) responses. Francisella tularensis is a facultative intracellular bacterium that activates both Th1 and Th17 protective immune responses. Herein, we report that IL-10-deficient mice (Il10-/-), despite having increased Th1 and Th17 responses, exhibit increased mortality after pulmonary infection with F. tularensis live vaccine strain. We demonstrate that the increased mortality observed in Il10-/--infected mice is due to exacerbated IL-17 production that causes increased neutrophil recruitment and associated lung pathology. Thus, although IL-17 is required for protective immunity against pulmonary infection with F. tularensis live vaccine strain, its production is tightly regulated by IL-10 to generate efficient induction of protective immunity without mediating pathology. These data suggest a critical role for IL-10 in maintaining the delicate balance between host immunity and pathology during pulmonary infection with F. tularensis live vaccine strain.

Original languageEnglish
Pages (from-to)1397-1404
Number of pages8
JournalAmerican Journal of Pathology
Volume183
Issue number5
DOIs
StatePublished - Nov 2013

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