IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice

Kordula Kautz-Neu; Susanna L. Kostka; Stephanie Dinges; Yoichiro Iwakura; Mark C. Udey; Esther Von Stebut

doi:10.1111/j.1600-0625.2010.01172.x

IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice

Kordula Kautz-Neu, Susanna L. Kostka, Stephanie Dinges, Yoichiro Iwakura, Mark C. Udey, Esther Von Stebut

Division of Dermatology

Research output: Contribution to journal › Letter › peer-review

30 Scopus citations

Abstract

Leishmaniasis is a parasitic disease affecting 12 million people. Control of infection (e.g. in C57BL/6 mice) results from IL12dependent production of IFNγ by Th1/Tc1 cells. In contrast, BALB/c mice succumb to infection because of preferential Th2 type cytokine induction. Infected dendritic cells (DC) represent important sources of IL 12. Genetically determined differences in DC IL 1α/β production contribute to disease outcome. Whereas the course of disease was not dramatically altered in IL 1RI^-/- mice, local administration of IL 1α to infected C57BL/6 mice improved disease outcome. To definitively elucidate the involvement of IL 1 in immunity against leishmaniasis, we now utilized IL 1α/β double-deficient C57BL/6 mice. C57BL/6 mice are believed to be a good surrogate model for human, self limited cutaneous leishmaniasis (CL). Leishmania major-infected IL 1α/β^-/- mice were resistant to experimental CL comparable to controls. In addition, DC-based vaccination against leishmaniasis in C57BL/6 mice was independent of IL-1. Thus, in Leishmania-resistant C57BL/6 mice, IL-1 signalling is dispensable for protection.

Original language	English
Pages (from-to)	76-78
Number of pages	3
Journal	Experimental Dermatology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0625.2010.01172.x
State	Published - Jan 2011

Keywords

Dendritic cells
IL-1
L. major

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title = "IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice",

abstract = "Leishmaniasis is a parasitic disease affecting 12 million people. Control of infection (e.g. in C57BL/6 mice) results from IL12dependent production of IFNγ by Th1/Tc1 cells. In contrast, BALB/c mice succumb to infection because of preferential Th2 type cytokine induction. Infected dendritic cells (DC) represent important sources of IL 12. Genetically determined differences in DC IL 1α/β production contribute to disease outcome. Whereas the course of disease was not dramatically altered in IL 1RI-/- mice, local administration of IL 1α to infected C57BL/6 mice improved disease outcome. To definitively elucidate the involvement of IL 1 in immunity against leishmaniasis, we now utilized IL 1α/β double-deficient C57BL/6 mice. C57BL/6 mice are believed to be a good surrogate model for human, self limited cutaneous leishmaniasis (CL). Leishmania major-infected IL 1α/β-/- mice were resistant to experimental CL comparable to controls. In addition, DC-based vaccination against leishmaniasis in C57BL/6 mice was independent of IL-1. Thus, in Leishmania-resistant C57BL/6 mice, IL-1 signalling is dispensable for protection.",

keywords = "Dendritic cells, IL-1, L. major",

author = "Kordula Kautz-Neu and Kostka, {Susanna L.} and Stephanie Dinges and Yoichiro Iwakura and Udey, {Mark C.} and {Von Stebut}, Esther",

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doi = "10.1111/j.1600-0625.2010.01172.x",

language = "English",

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AU - Kautz-Neu, Kordula

AU - Kostka, Susanna L.

AU - Dinges, Stephanie

AU - Iwakura, Yoichiro

AU - Udey, Mark C.

AU - Von Stebut, Esther

PY - 2011/1

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N2 - Leishmaniasis is a parasitic disease affecting 12 million people. Control of infection (e.g. in C57BL/6 mice) results from IL12dependent production of IFNγ by Th1/Tc1 cells. In contrast, BALB/c mice succumb to infection because of preferential Th2 type cytokine induction. Infected dendritic cells (DC) represent important sources of IL 12. Genetically determined differences in DC IL 1α/β production contribute to disease outcome. Whereas the course of disease was not dramatically altered in IL 1RI-/- mice, local administration of IL 1α to infected C57BL/6 mice improved disease outcome. To definitively elucidate the involvement of IL 1 in immunity against leishmaniasis, we now utilized IL 1α/β double-deficient C57BL/6 mice. C57BL/6 mice are believed to be a good surrogate model for human, self limited cutaneous leishmaniasis (CL). Leishmania major-infected IL 1α/β-/- mice were resistant to experimental CL comparable to controls. In addition, DC-based vaccination against leishmaniasis in C57BL/6 mice was independent of IL-1. Thus, in Leishmania-resistant C57BL/6 mice, IL-1 signalling is dispensable for protection.

AB - Leishmaniasis is a parasitic disease affecting 12 million people. Control of infection (e.g. in C57BL/6 mice) results from IL12dependent production of IFNγ by Th1/Tc1 cells. In contrast, BALB/c mice succumb to infection because of preferential Th2 type cytokine induction. Infected dendritic cells (DC) represent important sources of IL 12. Genetically determined differences in DC IL 1α/β production contribute to disease outcome. Whereas the course of disease was not dramatically altered in IL 1RI-/- mice, local administration of IL 1α to infected C57BL/6 mice improved disease outcome. To definitively elucidate the involvement of IL 1 in immunity against leishmaniasis, we now utilized IL 1α/β double-deficient C57BL/6 mice. C57BL/6 mice are believed to be a good surrogate model for human, self limited cutaneous leishmaniasis (CL). Leishmania major-infected IL 1α/β-/- mice were resistant to experimental CL comparable to controls. In addition, DC-based vaccination against leishmaniasis in C57BL/6 mice was independent of IL-1. Thus, in Leishmania-resistant C57BL/6 mice, IL-1 signalling is dispensable for protection.

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KW - L. major

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IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice

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Keywords

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