TY - JOUR
T1 - Igniting the slow burn of post-COVID conditions
AU - Henderson, Jeffrey P.
N1 - Publisher Copyright:
Copyright © 2023 Henderson.
PY - 2023/10
Y1 - 2023/10
N2 - Post-COVID conditions (PCCs) are persistent new patient symptoms occurring after acute COVID-19 infection and are an increasingly appreciated dimension of the COVID-19 pandemic. The factors that cause PCCs are not well understood. In recent work, Gebo et al. identify a connection between acute IL-6 levels, early COVID-19 convalescent plasma (CP) administration, and later PCCs in subjects from a randomized controlled trial of acutely ill subjects enrolled in 2020 to 2021 (K. A. Gebo, S. L. Heath, Y. Fukuta, X. Zhu, et al., mBio e00618-23, 2023, https://doi.org/10.1128/mbio.00618-23). These results may be viewed as part of an emerging picture linking the intensity of inflammatory responses during acute infection to later PCCs.
AB - Post-COVID conditions (PCCs) are persistent new patient symptoms occurring after acute COVID-19 infection and are an increasingly appreciated dimension of the COVID-19 pandemic. The factors that cause PCCs are not well understood. In recent work, Gebo et al. identify a connection between acute IL-6 levels, early COVID-19 convalescent plasma (CP) administration, and later PCCs in subjects from a randomized controlled trial of acutely ill subjects enrolled in 2020 to 2021 (K. A. Gebo, S. L. Heath, Y. Fukuta, X. Zhu, et al., mBio e00618-23, 2023, https://doi.org/10.1128/mbio.00618-23). These results may be viewed as part of an emerging picture linking the intensity of inflammatory responses during acute infection to later PCCs.
KW - antiviral agents
KW - convalescent plasma
KW - COVID-19
KW - post-COVID conditions
UR - http://www.scopus.com/inward/record.url?scp=85176606149&partnerID=8YFLogxK
U2 - 10.1128/mbio.01489-23
DO - 10.1128/mbio.01489-23
M3 - Review article
C2 - 37750708
AN - SCOPUS:85176606149
SN - 2161-2129
VL - 14
JO - mBio
JF - mBio
IS - 5
ER -