IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia

Andrew F. Malone; Matthew A. Sparks; David N. Howell; John Paul Middleton; Stephen R. Smith; Ruediger W. Lehrich

doi:10.5301/jn.5000298

IgG₄-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia

Andrew F. Malone, Matthew A. Sparks, David N. Howell, John Paul Middleton, Stephen R. Smith, Ruediger W. Lehrich

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG₄-related systemic diseases can affect many organ systems including the kidney and typically respond to corticosteroid treatment. Case: We present a case of IgG₄-related TIN in a patient with concomitant chronic lymphocytic leukemia. To our knowledge, IgG₄-related TIN has not been associated with any hematological disorder such as chronic lymphocytic leukemia. Conclusion: We propose that all kidney biopsies with significant plasma cell infiltrate should be stained for IgG₄ as response to treatment is common.

Original language	English
Pages (from-to)	1195-1198
Number of pages	4
Journal	Journal of Nephrology
Volume	26
Issue number	6
DOIs	https://doi.org/10.5301/jn.5000298
State	Published - Nov 1 2013

Keywords

CLL
IgG-related kidney disease
Tubulointerstitial kidney disease

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10.5301/jn.5000298

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title = "IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia",

abstract = "Background: Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG4-related systemic diseases can affect many organ systems including the kidney and typically respond to corticosteroid treatment. Case: We present a case of IgG4-related TIN in a patient with concomitant chronic lymphocytic leukemia. To our knowledge, IgG4-related TIN has not been associated with any hematological disorder such as chronic lymphocytic leukemia. Conclusion: We propose that all kidney biopsies with significant plasma cell infiltrate should be stained for IgG4 as response to treatment is common.",

keywords = "CLL, IgG-related kidney disease, Tubulointerstitial kidney disease",

author = "Malone, {Andrew F.} and Sparks, {Matthew A.} and Howell, {David N.} and Middleton, {John Paul} and Smith, {Stephen R.} and Lehrich, {Ruediger W.}",

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T1 - IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia

AU - Malone, Andrew F.

AU - Sparks, Matthew A.

AU - Howell, David N.

AU - Middleton, John Paul

AU - Smith, Stephen R.

AU - Lehrich, Ruediger W.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Background: Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG4-related systemic diseases can affect many organ systems including the kidney and typically respond to corticosteroid treatment. Case: We present a case of IgG4-related TIN in a patient with concomitant chronic lymphocytic leukemia. To our knowledge, IgG4-related TIN has not been associated with any hematological disorder such as chronic lymphocytic leukemia. Conclusion: We propose that all kidney biopsies with significant plasma cell infiltrate should be stained for IgG4 as response to treatment is common.

AB - Background: Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG4-related systemic diseases can affect many organ systems including the kidney and typically respond to corticosteroid treatment. Case: We present a case of IgG4-related TIN in a patient with concomitant chronic lymphocytic leukemia. To our knowledge, IgG4-related TIN has not been associated with any hematological disorder such as chronic lymphocytic leukemia. Conclusion: We propose that all kidney biopsies with significant plasma cell infiltrate should be stained for IgG4 as response to treatment is common.

KW - CLL

KW - IgG-related kidney disease

KW - Tubulointerstitial kidney disease

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JO - Journal of Nephrology

JF - Journal of Nephrology

SN - 1121-8428

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ER -

IgG₄-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia

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