IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia

Andrew F. Malone, Matthew A. Sparks, David N. Howell, John Paul Middleton, Stephen R. Smith, Ruediger W. Lehrich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG4-related systemic diseases can affect many organ systems including the kidney and typically respond to corticosteroid treatment. Case: We present a case of IgG4-related TIN in a patient with concomitant chronic lymphocytic leukemia. To our knowledge, IgG4-related TIN has not been associated with any hematological disorder such as chronic lymphocytic leukemia. Conclusion: We propose that all kidney biopsies with significant plasma cell infiltrate should be stained for IgG4 as response to treatment is common.

Original languageEnglish
Pages (from-to)1195-1198
Number of pages4
JournalJournal of Nephrology
Volume26
Issue number6
DOIs
StatePublished - Nov 1 2013

Keywords

  • CLL
  • IgG-related kidney disease
  • Tubulointerstitial kidney disease

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