IgG responses to tissue-associated antigens as biomarkers of immunological treatment efficacy

Heath A. Smith, Brett B. Maricque, John Eberhardt, Benjamin Petersen, James L. Gulley, Jeffrey Schlom, Douglas G. McNeel

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer. In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies. Sera were obtained from prostate cancer patients prior to and three months following treatment with androgen deprivation therapy (n=34), a poxviral vaccine (n=31), and a DNA vaccine (n=21). Changes in IgG responses to individual antigens were identified by phage immunoblot. Patterns of IgG recognition following three months of treatment were evaluated using a machine-learned Bayesian Belief Network (ML-BBN). We found that different antigens were recognized following androgen deprivation compared with vaccine therapies. While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models.

Original languageEnglish
Article number454861
JournalJournal of Biomedicine and Biotechnology
Volume2011
DOIs
StatePublished - 2011

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