IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

Bruce A. Rosa, Mushtaq Ahmed, Dhiraj K. Singh, José Alberto Choreño-Parra, Journey Cole, Luis Armando Jiménez-Álvarez, Tatiana Sofía Rodríguez-Reyna, Bindu Singh, Olga Gonzalez, Ricardo Carrion, Larry S. Schlesinger, John Martin, Joaquín Zúñiga, Makedonka Mitreva, Deepak Kaushal, Shabaana A. Khader

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 infection, we have characterized the transcriptional signatures induced in the lungs of juvenile and old macaques following infection. Genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are significantly induced in macaque infected lungs, while pathways associated with collagen formation are downregulated, as also seen in lungs of macaques with tuberculosis. In COVID-19, increasing age is a significant risk factor for poor prognosis and increased mortality. Type I IFN and Notch signaling pathways are significantly upregulated in lungs of juvenile infected macaques when compared with old infected macaques. These results are corroborated with increased peripheral neutrophil counts and neutrophil lymphocyte ratio in older individuals with COVID-19 disease. Together, our transcriptomic studies have delineated disease pathways that improve our understanding of the immunopathogenesis of COVID-19.

Original languageEnglish
Article number290
JournalCommunications Biology
Volume4
Issue number1
DOIs
StatePublished - Dec 2021

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