Idiopathic intracranial hypertension (pseudotumor cerebri)

Sandeep Randhawa, Gregory P. Van Stavern

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


Purpose of review: To review the current standard of care in the diagnosis and treatment of idiopathic intracranial hypertension (IIH). We also discuss recent advances in the understanding of the pathogenesis of IIH with emerging trends in management of this syndrome. Recent findings There has been increasing literature suggesting a role of vitamin A, adipokines, sleep disorders, and venous sinus stenosis in the pathogenesis of IIH. Newer medical treatment options like topiramate and surgical treatment options like stereotactic ventriculoperitoneal shunting have been found to be attractive alternatives. There has also been an emerging interest in cerebral venous sinus stenting, though its role and utility remain debatable. Summary This article seeks to present a systematic approach to the management of IIH. Many newer treatment modalities are being explored for IIH refractory to standard medical therapy, but their efficacy and safety must be demonstrated in large studies before they can be adopted as part of standard treatment.

Original languageEnglish
Pages (from-to)445-456
Number of pages12
JournalCurrent Opinion in Ophthalmology
Issue number6
StatePublished - Nov 2008


  • Cerebrospinal fluid
  • Idiopathic intracranial hypertension
  • Intracranial pressure
  • Obesity
  • Papilledema
  • Pseudotumor cerebri
  • Venous sinus stenosis
  • Venous sinus stenting
  • Vitamin A


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