TY - JOUR
T1 - Idiopathic distal sensory polyneuropathy
T2 - ACTTION diagnostic criteria
AU - Freeman, Roy
AU - Gewandter, Jennifer S.
AU - Faber, Catharina G.
AU - Gibbons, Christopher
AU - Haroutounian, Simon
AU - Lauria, Giuseppe
AU - Levine, Todd
AU - Malik, Rayaz A.
AU - Singleton, J. Robinson
AU - Smith, A. Gordon
AU - Bell, Josh
AU - Dworkin, Robert H.
AU - Feldman, Eva
AU - Herrmann, David N.
AU - Hoke, Ahmet
AU - Kolb, Noah
AU - Mansikka, Heikki
AU - Oaklander, Anne Louise
AU - Peltier, Amanda
AU - Polydefkis, Michael
AU - Ritt, Elissa
AU - Russell, James W.
AU - Sainati, Stephen
AU - Steiner, Deborah
AU - Treister, Roi
AU - Üçeyler, Nurcan
N1 - Publisher Copyright:
© 2020 American Academy of Neurology.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - OBJECTIVE: To present standardized diagnostic criteria for idiopathic distal sensory polyneuropathy (iDSP) and its subtypes: idiopathic mixed fiber sensory neuropathy (iMFN), idiopathic small fiber sensory neuropathy (iSFN), and idiopathic large fiber sensory neuropathy (iLFN) for use in research. METHODS: The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities and Networks (ACTTION) public-private partnership with the Food and Drug Administration convened a meeting to develop consensus diagnostic criteria for iMFN, iSFN, and iLFN. After background presentations, a collaborative, iterative approach was used to develop expert consensus for new criteria. RESULTS: An iDSP diagnosis requires at least 1 small fiber (SF) or large fiber (LF) symptom, at least 1 SF or LF sign, abnormalities in sensory nerve conduction studies (NCS) or distal intraepidermal nerve fiber density (IENFD), and exclusion of known etiologies. An iMFN diagnosis requires that at least 1 of the above clinical features is SF and 1 clinical feature is LF with abnormalities in sensory NCS or IENFD. Diagnostic criteria for iSFN require at least 1 SF symptom and at least 1 SF sign with abnormal IENFD, normal sensory NCS, and the absence of LF symptoms and signs. Diagnostic criteria for iLFN require at least 1 LF symptom and at least 1 LF sign with normal IENFD, abnormal sensory NCS, and absence of SF symptoms and signs. CONCLUSION: Adoption of these standardized diagnostic criteria will advance research and clinical trials and spur development of novel therapies for iDSPs.
AB - OBJECTIVE: To present standardized diagnostic criteria for idiopathic distal sensory polyneuropathy (iDSP) and its subtypes: idiopathic mixed fiber sensory neuropathy (iMFN), idiopathic small fiber sensory neuropathy (iSFN), and idiopathic large fiber sensory neuropathy (iLFN) for use in research. METHODS: The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities and Networks (ACTTION) public-private partnership with the Food and Drug Administration convened a meeting to develop consensus diagnostic criteria for iMFN, iSFN, and iLFN. After background presentations, a collaborative, iterative approach was used to develop expert consensus for new criteria. RESULTS: An iDSP diagnosis requires at least 1 small fiber (SF) or large fiber (LF) symptom, at least 1 SF or LF sign, abnormalities in sensory nerve conduction studies (NCS) or distal intraepidermal nerve fiber density (IENFD), and exclusion of known etiologies. An iMFN diagnosis requires that at least 1 of the above clinical features is SF and 1 clinical feature is LF with abnormalities in sensory NCS or IENFD. Diagnostic criteria for iSFN require at least 1 SF symptom and at least 1 SF sign with abnormal IENFD, normal sensory NCS, and the absence of LF symptoms and signs. Diagnostic criteria for iLFN require at least 1 LF symptom and at least 1 LF sign with normal IENFD, abnormal sensory NCS, and absence of SF symptoms and signs. CONCLUSION: Adoption of these standardized diagnostic criteria will advance research and clinical trials and spur development of novel therapies for iDSPs.
UR - http://www.scopus.com/inward/record.url?scp=85097004519&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000010988
DO - 10.1212/WNL.0000000000010988
M3 - Review article
C2 - 33055271
AN - SCOPUS:85097004519
VL - 95
SP - 1005
EP - 1014
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 22
ER -