Summary: Retroviral integration has been implicated in several biomedical applications, including identification of cancerassociated genes and malignant transformation in gene therapy clinical trials. We introduce an efficient and scalable method for fast identification of viral vector integration sites from long read high-throughput sequencing. Individual sequence reads are masked to remove non-genomic sequence, aligned to the host genome and assembled into contiguous fragments used to pinpoint the position of integration.

Original languageEnglish
Article numberbtq722
Pages (from-to)720-722
Number of pages3
Issue number5
StatePublished - Mar 2011


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