Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity

Karolyn A. Oetjen; Colin S. Duckett

doi:10.1016/j.molcel.2011.05.018

Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity

Karolyn A. Oetjen
, Colin S. Duckett

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.

Original language	English
Pages (from-to)	553-554
Number of pages	2
Journal	Molecular cell
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2011.05.018
State	Published - Jun 10 2011

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title = "Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity",

abstract = "In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.",

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AU - Oetjen, Karolyn A.

AU - Duckett, Colin S.

PY - 2011/6/10

Y1 - 2011/6/10

N2 - In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.

AB - In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.

UR - https://www.scopus.com/pages/publications/79958021240

U2 - 10.1016/j.molcel.2011.05.018

DO - 10.1016/j.molcel.2011.05.018

M3 - Short survey

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AN - SCOPUS:79958021240

SN - 1097-2765

VL - 42

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JO - Molecular cell

JF - Molecular cell

IS - 5

ER -

Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity

Abstract

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