Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity

Karolyn A. Oetjen, Colin S. Duckett

Research output: Contribution to journalShort survey

2 Scopus citations

Abstract

In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.

Original languageEnglish
Pages (from-to)553-554
Number of pages2
JournalMolecular cell
Volume42
Issue number5
DOIs
StatePublished - Jun 10 2011
Externally publishedYes

Fingerprint Dive into the research topics of 'Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity'. Together they form a unique fingerprint.

Cite this