Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity

Karolyn A. Oetjen; Colin S. Duckett

doi:10.1016/j.molcel.2011.05.018

Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity

Karolyn A. Oetjen, Colin S. Duckett

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.

Original language	English
Pages (from-to)	553-554
Number of pages	2
Journal	Molecular cell
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2011.05.018
State	Published - Jun 10 2011

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abstract = "In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.",

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AU - Duckett, Colin S.

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AB - In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.

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Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity

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