TY - JOUR
T1 - Identifying the critical gaps in research on sex differences in metabolism across the life span
AU - Reusch, Jane E.B.
AU - Rajendra Kumar, T.
AU - Regensteiner, Judith G.
AU - Zeitler, Philip S.
AU - Arany, Zoltan
AU - Merz, Bairey
AU - Noel, C.
AU - Barrett-Connor, Elizabeth
AU - Boyle, Kristen
AU - Brown, Laura
AU - Clegg, Deborah
AU - Cree-Green, Melanie
AU - Dabelea, Dana
AU - Friedman, Jacob
AU - Goodyear, Laurie
AU - Graham,
AU - Hill-Golden, Sherita
AU - Huebschmann, Amy
AU - Jenkins, Marjorie
AU - Jensen, Michael
AU - Julian, Colleen
AU - Kelsey, Megan
AU - Kennedy, Brian
AU - Klemm, Dwight
AU - Kohrt, Wendy
AU - JoAnn, Lindenfeld
AU - Moreau, Kerrie
AU - Nadeau, Kristen
AU - Lee, Nelson J.
AU - Nicklas, Jacinda
AU - Peterson, Linda
AU - Roberts, Jim
AU - Rudolph, Michael
AU - Sadovsky, Yoel
AU - Santoro, Nanette
AU - Snell-Bergeon, Janet
AU - Wenger, Nanette
N1 - Publisher Copyright:
Copyright © 2018 Endocrine Society.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The National Institutes of Health (NIH) Office of Research in Women’s Health now functions under a mandate calling for the systematic inclusion of both female and male cells, animals, and human subjects in all types of research, so that sex as a biological variable is understood in health and disease. Sex-specific data can improve disease prevention, diagnosis, and treatment as well as reduce inequities. Inclusion of women in research studies has modestly improved over the last 20 years, yet preclinical research is still primarily done using male animal models and male-derived cells, with the result that many conclusions are made based on incomplete and sex-biased data. There are important, yet poorly studied, sex differences in cardiometabolic disease. To begin to address these sex differences, the Center for Women’s Health Research at the University of Colorado held its inaugural National Conference, “Sex Differences Across the Lifespan: A Focus on Metabolism,” in September 2016 ([email protected]). Research to address the important goal of understanding key sex differences in cardiometabolic disease across the life span is lacking. The goal of this article is to discuss the current state of research addressing sex differences in cardiometabolic health across the life span, to outline critical research gaps that must be addressed in response to NIH mandates, and, importantly, to develop strategies to address sex as a biological variable to understand disease mechanisms as well as develop diagnostic and therapeutic modalities.
AB - The National Institutes of Health (NIH) Office of Research in Women’s Health now functions under a mandate calling for the systematic inclusion of both female and male cells, animals, and human subjects in all types of research, so that sex as a biological variable is understood in health and disease. Sex-specific data can improve disease prevention, diagnosis, and treatment as well as reduce inequities. Inclusion of women in research studies has modestly improved over the last 20 years, yet preclinical research is still primarily done using male animal models and male-derived cells, with the result that many conclusions are made based on incomplete and sex-biased data. There are important, yet poorly studied, sex differences in cardiometabolic disease. To begin to address these sex differences, the Center for Women’s Health Research at the University of Colorado held its inaugural National Conference, “Sex Differences Across the Lifespan: A Focus on Metabolism,” in September 2016 ([email protected]). Research to address the important goal of understanding key sex differences in cardiometabolic disease across the life span is lacking. The goal of this article is to discuss the current state of research addressing sex differences in cardiometabolic health across the life span, to outline critical research gaps that must be addressed in response to NIH mandates, and, importantly, to develop strategies to address sex as a biological variable to understand disease mechanisms as well as develop diagnostic and therapeutic modalities.
UR - http://www.scopus.com/inward/record.url?scp=85040730757&partnerID=8YFLogxK
U2 - 10.1210/en.2017-03019
DO - 10.1210/en.2017-03019
M3 - Review article
C2 - 29300998
AN - SCOPUS:85040730757
SN - 0013-7227
VL - 159
SP - 9
EP - 19
JO - Endocrinology (United States)
JF - Endocrinology (United States)
IS - 1
ER -