Identifying targets to prevent aminoglycoside ototoxicity

Jinkyung Kim, Sriram Hemachandran, Alan G. Cheng, Anthony J. Ricci

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we review recent advances in our understanding of aminoglycoside ototoxicity, mechanisms of drug transport, and promising sites for intervention to prevent ototoxicity.

Original languageEnglish
Article number103722
JournalMolecular and Cellular Neuroscience
Volume120
DOIs
StatePublished - May 2022

Keywords

  • Aminoglycoside
  • Cochlea
  • Hair cell
  • Ototoxicity

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