@article{bebb1137e6194e3c987fdefc5ecd2007,
title = "Identifying preclinical Alzheimer's disease using everyday driving behavior: Proof of concept",
abstract = "We examined whether driving behavior can predict preclinical Alzheimer's disease (AD). Data from 131 cognitively normal older adults with cerebrospinal fluid (CSF) and/or positron emission tomography (PET) biomarkers were examined with naturalistic driving behavior. Receiver operating characteristic curves were used to predict the highest 10%, 25%, and 50% of values for CSF tau/Aβ42, ptau181/Aβ42, or amyloid PET. Six in vivo driving variables alone yielded area under the curves (AUC) from 0.64-0.82. Addition of age, Apolipoprotein ε4, and neuropsychological measures to the models improved the AUC (0.81 to 0.90). Driving can be used as novel neurobehavioral marker to identify presence of preclinical AD.",
keywords = "Aging drivers, Alzheimer's disease, Biomarkers, Driving decline, Preclinical",
author = "Babulal, {Ganesh M.} and Ann Johnson and Fagan, {Anne M.} and Morris, {John C.} and Roe, {Catherine M.}",
note = "Funding Information: This research was funded by the National Institute on Aging [NIA, R01AG043434, R01AG056466, R01 AG067428, R01AG068183, P50AG005681, P01AG 003991, P01AG026276]; Fred Simmons and Olga Mohan, the Farrell Family Research Fund and the Charles and Joanne Knight Alzheimer Research Initiative of the Washington University Knight Alzheimer Disease Research Center (ADRC). The authors would like to express their gratitude to the research volunteers who participated in the studies from which these data were obtained and their supportive families. The authors would like to thank the Clinical, Biomarker and Imaging Cores at the Knight Alzheimer Disease Research Center for sample and data collection. Publisher Copyright: {\textcopyright} 2021 - IOS Press. All rights reserved.",
year = "2021",
doi = "10.3233/JAD-201294",
language = "English",
volume = "79",
pages = "1009--1014",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
number = "3",
}