@article{e1ba659cc283402cacdf3c035e1acc56,
title = "Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model",
abstract = "Despite the neurocognitive risks of aging with HIV, initial cross-sectional data suggest a subpopulation of older people with HIV (PWH) possess youthful neurocognition (NC) characteristic of SuperAgers (SA). Here we characterize longitudinal NC trajectories of older PWH and their convergent validity with baseline SA status, per established SuperAging criteria in PWH, and baseline biopsychosocial factors. Growth mixture modeling (GMM) identified longitudinal NC classes in 184 older (age ≥ 50-years) PWH with 1–5 years of follow-up. Classes were defined using {\textquoteleft}peak-age{\textquoteright} global T-scores, which compare performance to a normative sample of 25-year-olds. 3-classes were identified: Class 1Stable Elite (n = 31 [16.8%], high baseline peak-age T-scores with flat trajectory); Class 2Quadratic Average (n = 100 [54.3%], intermediate baseline peak-age T-scores with u-shaped trajectory); Class 3Quadratic Low (n = 53 [28.8%], low baseline peak-age T-scores with u-shaped trajectory). Baseline predictors of Class 1Stable Elite included SA status, younger age, higher cognitive and physiologic reserve, and fewer subjective cognitive difficulties. This GMM analysis supports the construct validity of SuperAging in older PWH through identification of a subgroup with longitudinally-stable, youthful neurocognition and robust biopsychosocial health.",
keywords = "Cognitive reserve, Comorbidity burden, Growth mixture model, HIV-associated neurocognitive disorder, SuperAging",
author = "{for the CHARTER Study Group} and Rowan Saloner and Lobo, {Judith D.} and Paolillo, {Emily W.} and Campbell, {Laura M.} and Letendre, {Scott L.} and Mariana Cherner and Igor Grant and Heaton, {Robert K.} and Ellis, {Ronald J.} and Roesch, {Scott C.} and Moore, {David J.} and Igor Grant and Letendre, {Scott L.} and Ellis, {Ronald J.} and Marcotte, {Thomas D.} and Donald Franklin and McCutchan, {J. Allen} and Smith, {Davey M.} and Heaton, {Robert K.} and Atkinson, {J. Hampton} and Matthew Dawson and Christine Fennema-Notestine and Taylor, {Michael J.} and Rebecca Theilmann and Gamst, {Anthony C.} and Clint Cushman and Ian Abramson and Florin Vaida and Ned Sacktor and Vincent Rogalski and Susan Morgello and David Simpson and Letty Mintz and McCutchan, {J. Allen} and Ann Collier and Christina Marra and Sher Storey and Benjamin Gelman and Eleanor Head and David Clifford and Muhammad Al-Lozi and Mengesha Teshome",
note = "Funding Information: This work was supported in part by awards from National Institutes of Health (the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) N01 MH2205 and HHSN271201000036C to IG; R01 MH107345 to RKH and SL; F31 AG064989 to RS; T32DA031098 to JDL; F31 AA027198 to EWP; and F31 AG067869 to LMC). The views expressed in this article are those of the authors and do not reflect the official policy or position of the United States Government. Funding Information: We gratefully acknowledge all individuals who participated in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) studies, as well as all CHARTER study investigators. The CHARTER group is affiliated with Johns Hopkins University; the Icahn School of Medicine at Mount Sinai; University of California, San Diego; University of Texas, Galveston; University of Washington, Seattle; Washington University, St. Louis; and is headquartered at the University of California, San Diego and includes: Director: Igor Grant, M.D.; Co-Directors: Scott L. Letendre, M.D., Ronald J. Ellis, M.D., Ph.D., Thomas D. Marcotte, Ph.D.; Center Manager: Donald Franklin, Jr.; Neuromedical Component: Ronald J. Ellis, M.D., Ph.D. (P.I.), J. Allen McCutchan, M.D.; Laboratory and Virology Component: Scott Letendre, M.D. (Co-P.I.), Davey M. Smith, M.D. (Co-P.I.).; Neurobehavioral Component: Robert K. Heaton, Ph.D. (P.I.), J. Hampton Atkinson, M.D., Matthew Dawson; Imaging Component: Christine Fennema-Notestine, Ph.D. (P.I.), Michael J Taylor, Ph.D., Rebecca Theilmann, Ph.D.; Data Management Component: Anthony C. Gamst, Ph.D. (P.I.), Clint Cushman; Statistics Component: Ian Abramson, Ph.D. (P.I.), Florin Vaida, Ph.D.; Johns Hopkins University Site: Ned Sacktor (P.I.), Vincent Rogalski; Icahn School of Medicine at Mount Sinai Site: Susan Morgello, M.D. (Co-P.I.) and David Simpson, M.D. (Co-P.I.), Letty Mintz, N.P.; University of California, San Diego Site: J. Allen McCutchan, M.D. (P.I.); University of Washington, Seattle Site: Ann Collier, M.D. (Co-P.I.) and Christina Marra, M.D. (Co-P.I.), Sher Storey, PA-C.; University of Texas, Galveston Site: Benjamin Gelman, M.D., Ph.D. (P.I.), Eleanor Head, R.N., B.S.N.; and Washington University, St. Louis Site: David Clifford, M.D. (P.I.), Muhammad Al-Lozi, M.D., Mengesha Teshome, M.D. We would also like to thank our colleague, Al{\'a}n Perez-Tejeda, for providing a Spanish translation of the abstract. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2022",
month = jun,
doi = "10.1007/s10461-021-03546-9",
language = "English",
volume = "26",
pages = "1966--1979",
journal = "AIDS and Behavior",
issn = "1090-7165",
number = "6",
}