Identification of two Calcium-Binding Proteins in Human Small Intestine: A preliminary report

David H. Alpers, Sook Won Lee, Louis V. Avioli

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

At least two separate proteins with calcium-binding activity have been detected in the human duodenum. One of these proteins migrates rapidly during electrophoresis, has a molecular weight of about 20,000 (similar to the vitamin D-sensitive protein in the chick or monkey), and contains no detectable carbohydrate or phosphate. Whether it is vitamin D-dependent is as yet uncertain. The activity of the calcium-binding protein has been found to vary linearly as a function of the background binding activity of the resin used in the assay. Accurate determinations of calcium-binding activity depend, therefore, upon correction of all values to correspond to a standard background binding activity.

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalGastroenterology
Volume62
Issue number4
DOIs
StatePublished - 1972

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