Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Zhuoming Liu, Laura A. VanBlargan, Louis Marie Bloyet, Paul W. Rothlauf, Rita E. Chen, Spencer Stumpf, Haiyan Zhao, John M. Errico, Elitza S. Theel, Mariel J. Liebeskind, Brynn Alford, William J. Buchser, Ali H. Ellebedy, Daved H. Fremont, Michael S. Diamond, Sean P.J. Whelan

Research output: Contribution to journalArticlepeer-review

182 Scopus citations

Abstract

Liu et al. isolated 50 escape mutants to 19 monoclonal antibodies targeting the SARS-CoV-2 spike using a VSV-SARS2 chimera. Some mutants (S477N) resist neutralization by multiple mAbs, and others (E484K) are less sensitive to neutralization by convalescent sera. Several mutants exist in clinical SARS2-CoV-2 isolates and thus warrant further study.

Original languageEnglish
Pages (from-to)477-488.e4
JournalCell Host and Microbe
Volume29
Issue number3
DOIs
StatePublished - Mar 10 2021

Keywords

  • ACE2 receptor decoys
  • COVID-19 vaccines
  • SARS-CoV-2 escape mutants
  • convalescent sera
  • coronaviruses
  • monoclonal antibodies
  • receptor-binding domain

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