Identification of proteins differentially expressed during chondrogenesis of mesenchymal cells

Sun Joo Lee, Hong Bae Jeon, Jeung Hwa Lee, Jong Shin Yoo, Jang Soo Chun, Yung Joon Yoo

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19 Scopus citations


We performed comparative proteome analysis of mesenchymal cells and chondrocytes to identify proteins differentially expressed during chondrogenesis. Nine such proteins were identified. Type II collagen, matrilin-1, carbonic anhydrase-II (CA-II), 3′-phosphoadenosine 5′-phosphosulfate (PAPS) synthetase-2, and aldo-keto reductase were increased during chondrogenesis, whereas cellular retinoic acid binding protein-I (CRABP-I), CRABP-II, cytoplasmic type 5 actin, and fatty acid binding protein were decreased or almost disappeared. Expression of type II collagen, matrilin-1, PAPS synthetase-2, and CA-II was regulated by extracellular signal-regulated protein kinase, protein kinase C, and p38 kinase, signaling molecules known to regulate chondrogenesis.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalFEBS Letters
Issue number1-3
StatePublished - Apr 9 2004


  • AKR, aldo-keto reductase
  • CA-II, carbonic anhydrase-II
  • CRABP, cellular retinoic acid binding protein
  • Chondrocyte
  • Chondrogenesis
  • ECM, extracellular matrix
  • Extracellular matrix
  • FABP, fatty acid binding protein
  • Mesenchymal cell
  • Signaling pathway


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