TY - JOUR
T1 - Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library
AU - Carroll, Carolyn Dilanni
AU - Patel, Hitesh
AU - Johnson, Theodore O.
AU - Guo, Tao
AU - Orlowski, Marc
AU - He, Zhen Min
AU - Cavallaro, Cullen L.
AU - Guo, Joan
AU - Oksman, Anna
AU - Gluzman, Ilya Y.
AU - Connelly, James
AU - Chelsky, Daniel
AU - Goldberg, Daniel E.
AU - Dolle, Roland E.
N1 - Funding Information:
Acknowledgments. We would like to thank Dr. Sergei V. Gulnik and Dr. John W. Eriekson (National Cancer Institute) for providing an initial supply of a cathepsin D substrate. We would also like to thank Dr. Nolan H. Sigal and Dr. John J. Baldwin for their support of this project. The work at Washington University was supported by UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR).
PY - 1998/9/8
Y1 - 1998/9/8
N2 - An encoded 13,020-member combinatorial library was synthesized containing a statine core. Evaluation of this library with plasmepsin II, an aspartyl protease required for hemoglobin metabolism in the malaria parasite, led to the identification of potent and selective inhibitors as well as novel structure-activity relationships.
AB - An encoded 13,020-member combinatorial library was synthesized containing a statine core. Evaluation of this library with plasmepsin II, an aspartyl protease required for hemoglobin metabolism in the malaria parasite, led to the identification of potent and selective inhibitors as well as novel structure-activity relationships.
UR - http://www.scopus.com/inward/record.url?scp=0032497354&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00419-3
DO - 10.1016/S0960-894X(98)00419-3
M3 - Article
C2 - 9873534
AN - SCOPUS:0032497354
SN - 0960-894X
VL - 8
SP - 2315
EP - 2320
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 17
ER -