Identification of mammaglobin B, a novel member of the uteroglobin gene family

Robert M. Becker, Christopher Darrow, Drazen B. Zimonjic, Nicholas C. Popescu, Mark A. Watson, Timothy P. Fleming

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up- regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.

Original languageEnglish
Pages (from-to)70-78
Number of pages9
JournalGenomics
Volume54
Issue number1
DOIs
StatePublished - Nov 15 1998

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