TY - JOUR
T1 - Identification of mammaglobin B, a novel member of the uteroglobin gene family
AU - Becker, Robert M.
AU - Darrow, Christopher
AU - Zimonjic, Drazen B.
AU - Popescu, Nicholas C.
AU - Watson, Mark A.
AU - Fleming, Timothy P.
N1 - Funding Information:
This work was supported by NIH Grant CA 76227-01. Funds were provided by the Barnes/Jewish Hospital Auxiliary Fund.
PY - 1998/11/15
Y1 - 1998/11/15
N2 - In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up- regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.
AB - In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up- regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.
UR - http://www.scopus.com/inward/record.url?scp=0032533921&partnerID=8YFLogxK
U2 - 10.1006/geno.1998.5539
DO - 10.1006/geno.1998.5539
M3 - Article
C2 - 9806831
AN - SCOPUS:0032533921
SN - 0888-7543
VL - 54
SP - 70
EP - 78
JO - Genomics
JF - Genomics
IS - 1
ER -