Identification of dystrophic sympathetic axons in experimental diabetic autonomic neuropathy

H. Brent Clark; Robert E. Schmidt

doi:10.1016/0006-8993(84)91250-2

Identification of dystrophic sympathetic axons in experimental diabetic autonomic neuropathy

H. Brent Clark
, Robert E. Schmidt

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Markedly dilated dystrophic post-ganglionic sympathetic axons have been identified by dopamine-β-hydroxylase immunohistochemistry in the paravascular ileal mesenteric nerves of rats with chronic streptozotocin diabetes. Many axons contained multiple dilatations with interposed axonal segments of near normal dimensions. These axonal abnormalities were absent in control animals. The time course of the development of the axonopathy and its distribution in the alimentary tract correlate with quantitative ultrastructural findings previously reported in this system.

Original language	English
Pages (from-to)	390-395
Number of pages	6
Journal	Brain Research
Volume	293
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)91250-2
State	Published - Feb 20 1984

Keywords

autonomic (sympathetic) neuropathy
axonal dystrophy
experimental diabetes

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10.1016/0006-8993(84)91250-2

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title = "Identification of dystrophic sympathetic axons in experimental diabetic autonomic neuropathy",

abstract = "Markedly dilated dystrophic post-ganglionic sympathetic axons have been identified by dopamine-β-hydroxylase immunohistochemistry in the paravascular ileal mesenteric nerves of rats with chronic streptozotocin diabetes. Many axons contained multiple dilatations with interposed axonal segments of near normal dimensions. These axonal abnormalities were absent in control animals. The time course of the development of the axonopathy and its distribution in the alimentary tract correlate with quantitative ultrastructural findings previously reported in this system.",

keywords = "autonomic (sympathetic) neuropathy, axonal dystrophy, experimental diabetes",

author = "Clark, \{H. Brent\} and Schmidt, \{Robert E.\}",

note = "Funding Information: We would like to thank Dr. Boyd K. Hartman for providing the antibody to DBH. The assistance of Dr. Santiago B. Plurad in the ultrastructural investigations is gratefully acknowledged. Streptozotocin was kindly provided by the Up john Company. This study was supported by NIH Grant AM19645, Research Grant 81R-425 from the Juvenile Diabetes Foundation, and Biomedical Research Support Grant 3155-51420.",

year = "1984",

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doi = "10.1016/0006-8993(84)91250-2",

language = "English",

volume = "293",

pages = "390--395",

journal = "Brain Research",

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T1 - Identification of dystrophic sympathetic axons in experimental diabetic autonomic neuropathy

AU - Clark, H. Brent

AU - Schmidt, Robert E.

N1 - Funding Information: We would like to thank Dr. Boyd K. Hartman for providing the antibody to DBH. The assistance of Dr. Santiago B. Plurad in the ultrastructural investigations is gratefully acknowledged. Streptozotocin was kindly provided by the Up john Company. This study was supported by NIH Grant AM19645, Research Grant 81R-425 from the Juvenile Diabetes Foundation, and Biomedical Research Support Grant 3155-51420.

PY - 1984/2/20

Y1 - 1984/2/20

N2 - Markedly dilated dystrophic post-ganglionic sympathetic axons have been identified by dopamine-β-hydroxylase immunohistochemistry in the paravascular ileal mesenteric nerves of rats with chronic streptozotocin diabetes. Many axons contained multiple dilatations with interposed axonal segments of near normal dimensions. These axonal abnormalities were absent in control animals. The time course of the development of the axonopathy and its distribution in the alimentary tract correlate with quantitative ultrastructural findings previously reported in this system.

AB - Markedly dilated dystrophic post-ganglionic sympathetic axons have been identified by dopamine-β-hydroxylase immunohistochemistry in the paravascular ileal mesenteric nerves of rats with chronic streptozotocin diabetes. Many axons contained multiple dilatations with interposed axonal segments of near normal dimensions. These axonal abnormalities were absent in control animals. The time course of the development of the axonopathy and its distribution in the alimentary tract correlate with quantitative ultrastructural findings previously reported in this system.

KW - autonomic (sympathetic) neuropathy

KW - axonal dystrophy

KW - experimental diabetes

UR - https://www.scopus.com/pages/publications/0021326608

U2 - 10.1016/0006-8993(84)91250-2

DO - 10.1016/0006-8993(84)91250-2

M3 - Article

C2 - 6230137

AN - SCOPUS:0021326608

SN - 0006-8993

VL - 293

SP - 390

EP - 395

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Identification of dystrophic sympathetic axons in experimental diabetic autonomic neuropathy

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