TY - JOUR
T1 - Identification of an endocrine disrupting agent from corn with mitogenic activity
AU - Markaverich, Barry M.
AU - Alejandro, Mary Ann
AU - Markaverich, David
AU - Zitzow, Lois
AU - Casajuna, Nancy
AU - Camarao, Nathan
AU - Hill, Jamal
AU - Bhirdo, Ken
AU - Faith, Robert
AU - Turk, John
AU - Crowley, Jan R.
PY - 2002
Y1 - 2002
N2 - A mitogenic agent in corncob bedding and fresh corn products disrupts sexual behavior and estrous cyclicity in rats. The mitogenic activity resides in an isomeric mixture of linoleic acid derivatives with a tetrahydrofuran ring and two hydroxyl groups (THF-diols) that include 9, (12)-oxy-10, 13-dihydroxystearic acid and 10, (13)-oxy-9, 12-dihydroxystearic acid. Synthetic THF-diols stimulated breast cancer cell proliferation in vitro and disrupted the estrous cycle in female rats at oral doses of ∼0.30 mg/kg body weight/day. Exposure to THF-diols may disrupt endocrine function in experimental animals at doses ∼200 times lower than classical phytoestrogens, promote proliferation of breast or prostate cancer, and adversely affect human health.
AB - A mitogenic agent in corncob bedding and fresh corn products disrupts sexual behavior and estrous cyclicity in rats. The mitogenic activity resides in an isomeric mixture of linoleic acid derivatives with a tetrahydrofuran ring and two hydroxyl groups (THF-diols) that include 9, (12)-oxy-10, 13-dihydroxystearic acid and 10, (13)-oxy-9, 12-dihydroxystearic acid. Synthetic THF-diols stimulated breast cancer cell proliferation in vitro and disrupted the estrous cycle in female rats at oral doses of ∼0.30 mg/kg body weight/day. Exposure to THF-diols may disrupt endocrine function in experimental animals at doses ∼200 times lower than classical phytoestrogens, promote proliferation of breast or prostate cancer, and adversely affect human health.
UR - http://www.scopus.com/inward/record.url?scp=0036299025&partnerID=8YFLogxK
U2 - 10.1006/bbrc.2002.6499
DO - 10.1006/bbrc.2002.6499
M3 - Article
C2 - 11855846
AN - SCOPUS:0036299025
SN - 0006-291X
VL - 291
SP - 692
EP - 700
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -