TY - GEN
T1 - Identification of a transversely isotropic material model for white matter in the brain
AU - Feng, Yuan
AU - Okamoto, Ruth J.
AU - Namani, Ravi
AU - Genin, Guy M.
AU - Bayly, Philip V.
PY - 2012
Y1 - 2012
N2 - Axonal fiber tracts in white matter of the brain form anisotropic structures. It is assumed that this structural anisotropy causes mechanical anisotropy, making white matter tissue stiffer along the axonal fiber direction. This, in turn, will affect the mechanical loading of axonal tracts during traumatic brain injury (TBI). The goal of this study is to use a combination of in-vitro tests to characterize the mechanical anisotropy of white matter and compare it to gray matter, which is thought to be structurally and mechanically isotropic. A more complete understanding of the mechanical anisotropy of brain tissue will provide more accurate information for computational simulations of brain injury.
AB - Axonal fiber tracts in white matter of the brain form anisotropic structures. It is assumed that this structural anisotropy causes mechanical anisotropy, making white matter tissue stiffer along the axonal fiber direction. This, in turn, will affect the mechanical loading of axonal tracts during traumatic brain injury (TBI). The goal of this study is to use a combination of in-vitro tests to characterize the mechanical anisotropy of white matter and compare it to gray matter, which is thought to be structurally and mechanically isotropic. A more complete understanding of the mechanical anisotropy of brain tissue will provide more accurate information for computational simulations of brain injury.
UR - http://www.scopus.com/inward/record.url?scp=84887272361&partnerID=8YFLogxK
U2 - 10.1115/IMECE2012-88610
DO - 10.1115/IMECE2012-88610
M3 - Conference contribution
AN - SCOPUS:84887272361
SN - 9780791845189
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 787
EP - 794
BT - Biomedical and Biotechnology
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012
Y2 - 9 November 2012 through 15 November 2012
ER -