Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

Mark P. Hamilton; Kimal Rajapakshe; Sean M. Hartig; Boris Reva; Michael D. McLellan; Cyriac Kandoth; Li Ding; Travis I. Zack; Preethi H. Gunaratne; David A. Wheeler; Cristian Coarfa; Sean E. McGuire

doi:10.1038/ncomms3730

Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

Mark P. Hamilton, Kimal Rajapakshe, Sean M. Hartig, Boris Reva, Michael D. McLellan, Cyriac Kandoth, Li Ding, Travis I. Zack, Preethi H. Gunaratne, David A. Wheeler, Cristian Coarfa, Sean E. McGuire

Research output: Contribution to journal › Article

81 Scopus citations

Abstract

MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA 'superfamily' consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members.

Original language	English
Article number	2730
Journal	Nature communications
Volume	4
DOIs	https://doi.org/10.1038/ncomms3730
State	Published - Jan 1 2013

Access to Document

10.1038/ncomms3730

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif'. Together they form a unique fingerprint.

Cite this

Hamilton, M. P., Rajapakshe, K., Hartig, S. M., Reva, B., McLellan, M. D., Kandoth, C., Ding, L., Zack, T. I., Gunaratne, P. H., Wheeler, D. A., Coarfa, C., & McGuire, S. E. (2013). Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nature communications, 4, [2730]. https://doi.org/10.1038/ncomms3730

@article{9a4f719ed06d4c7296506e109d44a4e2,

title = "Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif",

abstract = "MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA 'superfamily' consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members.",

author = "Hamilton, {Mark P.} and Kimal Rajapakshe and Hartig, {Sean M.} and Boris Reva and McLellan, {Michael D.} and Cyriac Kandoth and Li Ding and Zack, {Travis I.} and Gunaratne, {Preethi H.} and Wheeler, {David A.} and Cristian Coarfa and McGuire, {Sean E.}",

year = "2013",

month = jan,

day = "1",

doi = "10.1038/ncomms3730",

language = "English",

volume = "4",

journal = "Nature Communications",

issn = "2041-1723",

}

Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. / Hamilton, Mark P.; Rajapakshe, Kimal; Hartig, Sean M.; Reva, Boris; McLellan, Michael D.; Kandoth, Cyriac; Ding, Li; Zack, Travis I.; Gunaratne, Preethi H.; Wheeler, David A.; Coarfa, Cristian; McGuire, Sean E.

In: Nature communications, Vol. 4, 2730, 01.01.2013.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

AU - Hamilton, Mark P.

AU - Rajapakshe, Kimal

AU - Hartig, Sean M.

AU - Reva, Boris

AU - McLellan, Michael D.

AU - Kandoth, Cyriac

AU - Ding, Li

AU - Zack, Travis I.

AU - Gunaratne, Preethi H.

AU - Wheeler, David A.

AU - Coarfa, Cristian

AU - McGuire, Sean E.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA 'superfamily' consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members.

AB - MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA 'superfamily' consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members.

UR - http://www.scopus.com/inward/record.url?scp=84887641104&partnerID=8YFLogxK

U2 - 10.1038/ncomms3730

DO - 10.1038/ncomms3730

M3 - Article

C2 - 24220575

AN - SCOPUS:84887641104

VL - 4

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2730

ER -