TY - JOUR
T1 - Identification of a novel coronavirus from a beluga whale by using a panviral microarray
AU - Mihindukulasuriya, Kathie A.
AU - Wu, Guang
AU - St. Leger, Judy
AU - Nordhausen, Robert W.
AU - Wang, David
PY - 2008/5
Y1 - 2008/5
N2 - The emergence of viruses such as severe acute respiratory syndrome coronavirus and Nipah virus has underscored the role of animal reservoirs in human disease and the need for reservoir surveillance. Here, we used a panviral DNA microarray to investigate the death of a captive beluga whale in an aquatic park. A highly divergent coronavirus, tentatively named coronavirus SW1, was identified in liver tissue from the deceased whale. Subsequently, the entire genome of SW1 was sequenced, yielding a genome of 31,686 nucleotides. Phylogenetic analysis revealed SW1 to be a novel virus distantly related to but most similar to group III corona viruses.
AB - The emergence of viruses such as severe acute respiratory syndrome coronavirus and Nipah virus has underscored the role of animal reservoirs in human disease and the need for reservoir surveillance. Here, we used a panviral DNA microarray to investigate the death of a captive beluga whale in an aquatic park. A highly divergent coronavirus, tentatively named coronavirus SW1, was identified in liver tissue from the deceased whale. Subsequently, the entire genome of SW1 was sequenced, yielding a genome of 31,686 nucleotides. Phylogenetic analysis revealed SW1 to be a novel virus distantly related to but most similar to group III corona viruses.
UR - http://www.scopus.com/inward/record.url?scp=43249111857&partnerID=8YFLogxK
U2 - 10.1128/JVI.02722-07
DO - 10.1128/JVI.02722-07
M3 - Article
C2 - 18353961
AN - SCOPUS:43249111857
VL - 82
SP - 5084
EP - 5088
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 10
ER -