@article{ebf5ddf42f534e03bdf696875e1172f3,
title = "Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma",
abstract = "We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.",
keywords = "CELLCYCLE, DNA, HUMDISEASE",
author = "Houtan Noushmehr and Weisenberger, \{Daniel J.\} and Kristin Diefes and Phillips, \{Heidi S.\} and Kanan Pujara and Berman, \{Benjamin P.\} and Fei Pan and Pelloski, \{Christopher E.\} and Sulman, \{Erik P.\} and Bhat, \{Krishna P.\} and Verhaak, \{Roel G.W.\} and Hoadley, \{Katherine A.\} and Hayes, \{D. Neil\} and Perou, \{Charles M.\} and Schmidt, \{Heather K.\} and Li Ding and Wilson, \{Richard K.\} and \{Van Den Berg\}, David and Hui Shen and Henrik Bengtsson and Pierre Neuvial and Cope, \{Leslie M.\} and Jonathan Buckley and Herman, \{James G.\} and Baylin, \{Stephen B.\} and Laird, \{Peter W.\} and Kenneth Aldape",
note = "Funding Information: This work was supported by NIH/NCI grants U24 CA126561 and U24 CA143882-01 (P.W.L. and S.B.B.), grants from the M.D. Anderson Center for Cancer Epigenetics, the Brain Tumor Funders' Collaborative, the V Foundation, and the Rose Foundation, and SPORE grant P50CA127001 from NIH/NCI (K.A.). We thank Dennis Maglinte and members of the USC Epigenome Center for helpful discussions, Andreana Rivera for technical assistance, and Marisol Guerrero for editorial assistance. P.W.L. is a shareholder, consultant, and scientific advisory board member of Epigenomics, AG, which has a commercial interest in DNA methylation markers. This work was not supported by Epigenomics, AG. K.A. is a consultant and scientific advisory board member for Castle Biosciences, which has a commercial interest in molecular diagnostics. This work was not supported by Castle Biosciences. ",
year = "2010",
month = may,
day = "18",
doi = "10.1016/j.ccr.2010.03.017",
language = "English",
volume = "17",
pages = "510--522",
journal = "Cancer Cell",
issn = "1535-6108",
number = "5",
}