TY - JOUR
T1 - Identification and regulation of protein components of the apolipoprotein B mRNA editing enzyme - A complex event
AU - Anant, Shrikant
AU - Davidson, Nicholas O.
N1 - Funding Information:
Work quoted from the authors' laboratories was supported by grants from the National Institutes of Health (HL-38180, DK-56260 to N.O.D.) and a Foundation for Digestive Health and Nutrition Research Scholar Award to S.A. The authors gratefully acknowledge discussions with their colleagues, Drs. Valerie Blanc, Jeffrey Henderson, and Debnath Mukhophadyay, during the preparation of this review.
PY - 2002/10
Y1 - 2002/10
N2 - Apolipoprotein B (apoB) gene expression is regulated by transcriptional, posttranscriptional, and translational mechanisms in both small intestinal enterocytes and hepatocytes of all mammals. This review focuses on the posttranscriptional regulation of apoB gene expression - specifically, an enzymatic modification to the nuclear transcript referred to as C to U RNA editing. C to U RNA editing, the process responsible for the production of apoB-48, is an exquisitely precise process that targets a single nucleotide in over 14,000. RNA editing requires regulated interactions between core enzyme components whose identity is known and regulatory factors, most of which have yet to be fully characterized. This review summarizes information relevant to those transacting factors that are essential for editing activity (core factors) as well as those interacting partners (regulatory factors) whose physiological role in RNA editing is yet to be fully defined.
AB - Apolipoprotein B (apoB) gene expression is regulated by transcriptional, posttranscriptional, and translational mechanisms in both small intestinal enterocytes and hepatocytes of all mammals. This review focuses on the posttranscriptional regulation of apoB gene expression - specifically, an enzymatic modification to the nuclear transcript referred to as C to U RNA editing. C to U RNA editing, the process responsible for the production of apoB-48, is an exquisitely precise process that targets a single nucleotide in over 14,000. RNA editing requires regulated interactions between core enzyme components whose identity is known and regulatory factors, most of which have yet to be fully characterized. This review summarizes information relevant to those transacting factors that are essential for editing activity (core factors) as well as those interacting partners (regulatory factors) whose physiological role in RNA editing is yet to be fully defined.
UR - http://www.scopus.com/inward/record.url?scp=0036811663&partnerID=8YFLogxK
U2 - 10.1016/S1050-1738(02)00180-9
DO - 10.1016/S1050-1738(02)00180-9
M3 - Review article
C2 - 12458094
AN - SCOPUS:0036811663
SN - 1050-1738
VL - 12
SP - 311
EP - 317
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 7
ER -