Identification and Characterization of a Type III Polyketide Synthase Involved in Quinolone Alkaloid Biosynthesis from Aegle marmelos Correa

Mohankumar Saraladevi Resmi, Priyanka Verma, Rajesh S. Gokhale, Eppurathu Vasudevan Soniya

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Background: Type III polyketide synthase is hypothesized to produce quinolones, but no such enzyme has been identified so far. Results: QNS, a type III PKS from Aegle marmelos synthesizes diketide 4-hydroxy-1-methyl-2H-quinolone using a unique substrate binding site. Conclusion: QNS is a novel 4-hydroxy-1-methyl-2H-quinolone synthase. Significance: This is the first report of a gene involved in quinolone biosynthesis from plants.

Original languageEnglish
Pages (from-to)7271-7281
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number10
DOIs
StatePublished - Mar 8 2013

Fingerprint

Dive into the research topics of 'Identification and Characterization of a Type III Polyketide Synthase Involved in Quinolone Alkaloid Biosynthesis from Aegle marmelos Correa'. Together they form a unique fingerprint.

Cite this