Iatrogenic botulism due to therapeutic botulinum toxin A injection in a pediatric patient

Beth E. Crowner; Janice E. Brunstrom; Brad A. Racette

doi:10.1097/WNF.0b013e31804b1a0d

Iatrogenic botulism due to therapeutic botulinum toxin A injection in a pediatric patient

Beth E. Crowner, Janice E. Brunstrom, Brad A. Racette

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.

Original language	English
Pages (from-to)	310-313
Number of pages	4
Journal	Clinical Neuropharmacology
Volume	30
Issue number	5
DOIs	https://doi.org/10.1097/WNF.0b013e31804b1a0d
State	Published - Sep 2007

Keywords

Botulinum toxin A
Botulism
Cerebral palsy

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10.1097/WNF.0b013e31804b1a0d

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abstract = "Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.",

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N2 - Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.

AB - Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.

KW - Botulinum toxin A

KW - Botulism

KW - Cerebral palsy

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Iatrogenic botulism due to therapeutic botulinum toxin A injection in a pediatric patient

Abstract

Keywords

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