Hypozincemia during fever may trigger febrile convulsion

Y. Izumi, K. Ishii, K. Akiba, T. Hayashi

Research output: Contribution to journalArticle

22 Scopus citations


Febrile convulsions are generally thought to be induced by metabolic changes during the rise-phase of body temperature. The mechanism by which convulsions are induced, however, is not fully elucidated. In this article, we propose a new hypothesis about the induction mechanism of febrile convulsions that takes into account the hypozincemia during fever. This hypozincemia activates the NMDA receptor, one of the glutamate family of receptors, which may play an important role in the induction of epileptic discharge.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalMedical Hypotheses
Issue number1
StatePublished - May 1990
Externally publishedYes

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