Hypozincemia during fever may trigger febrile convulsion

Y. Izumi; K. Ishii; K. Akiba; T. Hayashi

doi:10.1016/0306-9877(90)90073-N

Hypozincemia during fever may trigger febrile convulsion

Y. Izumi, K. Ishii, K. Akiba, T. Hayashi

Division of Basic Science Research

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Abstract

Febrile convulsions are generally thought to be induced by metabolic changes during the rise-phase of body temperature. The mechanism by which convulsions are induced, however, is not fully elucidated. In this article, we propose a new hypothesis about the induction mechanism of febrile convulsions that takes into account the hypozincemia during fever. This hypozincemia activates the NMDA receptor, one of the glutamate family of receptors, which may play an important role in the induction of epileptic discharge.

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Medical Hypotheses
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/0306-9877(90)90073-N
State	Published - May 1990

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10.1016/0306-9877(90)90073-N

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title = "Hypozincemia during fever may trigger febrile convulsion",

abstract = "Febrile convulsions are generally thought to be induced by metabolic changes during the rise-phase of body temperature. The mechanism by which convulsions are induced, however, is not fully elucidated. In this article, we propose a new hypothesis about the induction mechanism of febrile convulsions that takes into account the hypozincemia during fever. This hypozincemia activates the NMDA receptor, one of the glutamate family of receptors, which may play an important role in the induction of epileptic discharge.",

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AU - Hayashi, T.

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N2 - Febrile convulsions are generally thought to be induced by metabolic changes during the rise-phase of body temperature. The mechanism by which convulsions are induced, however, is not fully elucidated. In this article, we propose a new hypothesis about the induction mechanism of febrile convulsions that takes into account the hypozincemia during fever. This hypozincemia activates the NMDA receptor, one of the glutamate family of receptors, which may play an important role in the induction of epileptic discharge.

AB - Febrile convulsions are generally thought to be induced by metabolic changes during the rise-phase of body temperature. The mechanism by which convulsions are induced, however, is not fully elucidated. In this article, we propose a new hypothesis about the induction mechanism of febrile convulsions that takes into account the hypozincemia during fever. This hypozincemia activates the NMDA receptor, one of the glutamate family of receptors, which may play an important role in the induction of epileptic discharge.

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Hypozincemia during fever may trigger febrile convulsion

Abstract

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