Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1α-mediated transcriptional regulation of their transporters

Keyphrases

• Transcriptional Regulation 100%
• Hypoxia 100%
• Microbiota 100%
• Hypoxia-inducible Transcription Factor 100%
• Colonic Uptake 100%
• Vitamin B1 100%
• Thiamine Pyrophosphate 71%
• NCI-H460 Cells 42%
• Thiamin Uptake 42%
• Thiamine 28%
• SLC19A2 28%
• Hypoxic Condition 28%
• Colonoids 28%
• SLC44A4 28%
• Knockdown 14%
• Inhibitory Effect 14%
• Small Interfering RNA (siRNA) 14%
• Gene Promoter 14%
• Nuclear Factor 14%
• Expression Level 14%
• Cellular Physiology 14%
• Gene-specific 14%
• Transcriptional Mechanism 14%
• Ex Vivo Model 14%
• Molecular Parameters 14%
• Desferrioxamine 14%
• SLC19A3 14%
• CAMP-responsive Element Binding Protein 14%

Biochemistry, Genetics and Molecular Biology

• Transcription Factors 100%
• Microflora 100%
• Fibrinogen 100%
• Thiamine 100%
• Thiamine Pyrophosphate 71%
• SLC19A2 28%
• Cell Function 14%
• Promoter Region 14%
• Binding Protein 14%
• Synapsin I 14%
• Gene Promoter 14%
• Cyclic Adenosine Monophosphate 14%
• Transcription Factor II 14%
• SLC19A3 14%

Medicine and Dentistry

• Transcription Factors 100%
• Fibrinogen 100%
• Thiamine 100%
• Hypoxia 100%
• Cocarboxylase 41%
• Deferoxamine 8%
• In Vitro 8%
• Nuclear Factor 8%
• Ex Vivo 8%
• Gut 8%
• Promoter Region 8%
• Cell Function 8%
• Synapsin I 8%
• Small Interfering RNA 8%
• Calcium Ion 8%
• Gene Promoter 8%
• Protein Binding 8%
• Transcription Factor II 8%
• Carbon Dioxide 8%