Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions

Laís P. Pral; José L. Fachi; Renan O. Corrêa; Marco Colonna; Marco A.R. Vinolo

doi:10.1016/j.it.2021.05.004

Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions

Laís P. Pral
, José L. Fachi
, Renan O. Corrêa
, Marco Colonna
, Marco A.R. Vinolo

Research output: Contribution to journal › Review article › peer-review

122 Scopus citations

Abstract

Oxygen (O₂) availability is a key factor regulating microbiota composition and the homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived metabolites increase O₂ consumption by intestinal epithelial cells (IECs), reducing its availability in the gut and leading to hypoxia. This physiological hypoxia activates cellular hypoxic sensors that adapt the metabolism and function of IECs and mucosa-resident cells, such as type-3 innate lymphoid cells (ILC3s). In this review, we discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (IECs and ILC3s) determine how the intestinal barrier and host–microbiota–pathogens connections are molded. Understanding these interactions might provide new treatment possibilities for dysbiosis, as well as certain inflammatory and infectious diseases.

Original language	English
Pages (from-to)	604-621
Number of pages	18
Journal	Trends in Immunology
Volume	42
Issue number	7
DOIs	https://doi.org/10.1016/j.it.2021.05.004
State	Published - Jul 2021

Keywords

innate lymphoid cells
intestinal epithelial cells
microbiota
short-chain fatty acids

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10.1016/j.it.2021.05.004

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title = "Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions",

abstract = "Oxygen (O2) availability is a key factor regulating microbiota composition and the homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived metabolites increase O2 consumption by intestinal epithelial cells (IECs), reducing its availability in the gut and leading to hypoxia. This physiological hypoxia activates cellular hypoxic sensors that adapt the metabolism and function of IECs and mucosa-resident cells, such as type-3 innate lymphoid cells (ILC3s). In this review, we discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (IECs and ILC3s) determine how the intestinal barrier and host–microbiota–pathogens connections are molded. Understanding these interactions might provide new treatment possibilities for dysbiosis, as well as certain inflammatory and infectious diseases.",

keywords = "innate lymphoid cells, intestinal epithelial cells, microbiota, short-chain fatty acids",

author = "Pral, \{La{\'i}s P.\} and Fachi, \{Jos{\'e} L.\} and Corr{\^e}a, \{Renan O.\} and Marco Colonna and Vinolo, \{Marco A.R.\}",

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year = "2021",

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doi = "10.1016/j.it.2021.05.004",

language = "English",

volume = "42",

pages = "604--621",

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TY - JOUR

T1 - Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions

AU - Pral, Laís P.

AU - Fachi, José L.

AU - Corrêa, Renan O.

AU - Colonna, Marco

AU - Vinolo, Marco A.R.

PY - 2021/7

Y1 - 2021/7

N2 - Oxygen (O2) availability is a key factor regulating microbiota composition and the homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived metabolites increase O2 consumption by intestinal epithelial cells (IECs), reducing its availability in the gut and leading to hypoxia. This physiological hypoxia activates cellular hypoxic sensors that adapt the metabolism and function of IECs and mucosa-resident cells, such as type-3 innate lymphoid cells (ILC3s). In this review, we discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (IECs and ILC3s) determine how the intestinal barrier and host–microbiota–pathogens connections are molded. Understanding these interactions might provide new treatment possibilities for dysbiosis, as well as certain inflammatory and infectious diseases.

AB - Oxygen (O2) availability is a key factor regulating microbiota composition and the homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived metabolites increase O2 consumption by intestinal epithelial cells (IECs), reducing its availability in the gut and leading to hypoxia. This physiological hypoxia activates cellular hypoxic sensors that adapt the metabolism and function of IECs and mucosa-resident cells, such as type-3 innate lymphoid cells (ILC3s). In this review, we discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (IECs and ILC3s) determine how the intestinal barrier and host–microbiota–pathogens connections are molded. Understanding these interactions might provide new treatment possibilities for dysbiosis, as well as certain inflammatory and infectious diseases.

KW - innate lymphoid cells

KW - intestinal epithelial cells

KW - microbiota

KW - short-chain fatty acids

UR - https://www.scopus.com/pages/publications/85108262715

U2 - 10.1016/j.it.2021.05.004

DO - 10.1016/j.it.2021.05.004

M3 - Review article

C2 - 34171295

AN - SCOPUS:85108262715

SN - 1471-4906

VL - 42

SP - 604

EP - 621

JO - Trends in Immunology

JF - Trends in Immunology

IS - 7

ER -

Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions

Abstract

Keywords

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