TY - JOUR
T1 - Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions
AU - Pral, Laís P.
AU - Fachi, José L.
AU - Corrêa, Renan O.
AU - Colonna, Marco
AU - Vinolo, Marco A.R.
N1 - Funding Information:
This study was supported by National Institutes of Health ( 1R01DK126969-01 ) and Fundação de Amparo à Pesquisa do Estado de São Paulo ( 18/15313–8 ). The study was also financed by the National Council for Scientific and Technological Development (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES)–Finance Code 001.L.P.P., J.L.F., and R.O.C are recipients of fellowships from FAPESP (2018/02208–1, 2017/06577–9, and 2016/23142-3, respectively). M.C. was supported by MIST ( U01AI095542 ).
Funding Information:
This study was supported by National Institutes of Health (1R01DK126969-01) and Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (18/15313?8). The study was also financed by the National Council for Scientific and Technological Development (CNPq) and Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - Brasil (CAPES)?Finance Code 001.L.P.P. J.L.F. and R.O.C are recipients of fellowships from FAPESP (2018/02208?1, 2017/06577?9, and 2016/23142-3, respectively). M.C. was supported by MIST (U01AI095542). The authors declare no competing interests.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/7
Y1 - 2021/7
N2 - Oxygen (O2) availability is a key factor regulating microbiota composition and the homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived metabolites increase O2 consumption by intestinal epithelial cells (IECs), reducing its availability in the gut and leading to hypoxia. This physiological hypoxia activates cellular hypoxic sensors that adapt the metabolism and function of IECs and mucosa-resident cells, such as type-3 innate lymphoid cells (ILC3s). In this review, we discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (IECs and ILC3s) determine how the intestinal barrier and host–microbiota–pathogens connections are molded. Understanding these interactions might provide new treatment possibilities for dysbiosis, as well as certain inflammatory and infectious diseases.
AB - Oxygen (O2) availability is a key factor regulating microbiota composition and the homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived metabolites increase O2 consumption by intestinal epithelial cells (IECs), reducing its availability in the gut and leading to hypoxia. This physiological hypoxia activates cellular hypoxic sensors that adapt the metabolism and function of IECs and mucosa-resident cells, such as type-3 innate lymphoid cells (ILC3s). In this review, we discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (IECs and ILC3s) determine how the intestinal barrier and host–microbiota–pathogens connections are molded. Understanding these interactions might provide new treatment possibilities for dysbiosis, as well as certain inflammatory and infectious diseases.
KW - innate lymphoid cells
KW - intestinal epithelial cells
KW - microbiota
KW - short-chain fatty acids
UR - http://www.scopus.com/inward/record.url?scp=85108262715&partnerID=8YFLogxK
U2 - 10.1016/j.it.2021.05.004
DO - 10.1016/j.it.2021.05.004
M3 - Review article
C2 - 34171295
AN - SCOPUS:85108262715
SN - 1471-4906
VL - 42
SP - 604
EP - 621
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -