Hypothermia protects the cochlea from noise damage

Kenneth R. Henry, Richard A. Chole

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Thresholds of the cochlear action potential were obtained from rodents at euthermic (38°C) and hypothermic (30° and 25°C) rectal temperatures. In the gerbil, low and middle frequency (1-8 kHz) thresholds increased an average of 2.3 dB per °C decrease of body temperature; at 16 kHz 3.5 dB/°C; and at 32 kHz, an increase of 4.4 dB/°C. In the mouse, these values were: 2-16 kHz 1.4 dB increase per °C decrease; 32 kHz 2.7 dB/°C; 64 kHz 3.8 dB/°C. When subjects maximally susceptible to permanent threshold shift (PTS) at low and middle frequencies (anesthetized, immature mice) were exposed to 115 dB noise, hypothermia reduced PTS at these most susceptible frequencies (2-16 kHz). When awake adult mice were exposed to this noise, hypothermia protected them from PTS at their most vulnerable frequency (32 kHz).

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalHearing research
Volume16
Issue number3
DOIs
StatePublished - Dec 1984
Externally publishedYes

Keywords

  • acoustic trauma
  • gerbil
  • hypothermia
  • mouse
  • permanent threshold shift
  • whole nerve action potential

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