Hypothalamic and preoptic area α1-receptor concentrations decrease, and cerebral cortical α1-receptor concentrations increase during postnatal maturation of male guinea pigs

Allan E. Johnson; Bruce Nock; Helena Ryer; Harvey Feder

doi:10.1159/000123898

Hypothalamic and preoptic area α₁-receptor concentrations decrease, and cerebral cortical α₁-receptor concentrations increase during postnatal maturation of male guinea pigs

Allan E. Johnson, Bruce Nock, Helena Ryer, Harvey Feder

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

α₁-Receptors were measured in intact male guinea pigs during the course of postnatal development. Receptor concentrations were significantly higher at day 1 in hypothalamus and at days 1 and 14 in preoptic area than at day 60. Conversely, in cerebral cortex, receptor concentrations were significantly lower in neonatal animals than in 60-day-old animals. There was no change in affinity of the receptor during development. Castration has no apparent effect on ai-receptor concentration in any brain area.

Original language	English
Pages (from-to)	243-247
Number of pages	5
Journal	Neuroendocrinology
Volume	38
Issue number	3
DOIs	https://doi.org/10.1159/000123898
State	Published - 1984

Keywords

Adrenoceptors
Androgen
Hypothalamus
Reproductive development

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title = "Hypothalamic and preoptic area α1-receptor concentrations decrease, and cerebral cortical α1-receptor concentrations increase during postnatal maturation of male guinea pigs",

abstract = "α1-Receptors were measured in intact male guinea pigs during the course of postnatal development. Receptor concentrations were significantly higher at day 1 in hypothalamus and at days 1 and 14 in preoptic area than at day 60. Conversely, in cerebral cortex, receptor concentrations were significantly lower in neonatal animals than in 60-day-old animals. There was no change in affinity of the receptor during development. Castration has no apparent effect on ai-receptor concentration in any brain area.",

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journal = "Neuroendocrinology",

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T1 - Hypothalamic and preoptic area α1-receptor concentrations decrease, and cerebral cortical α1-receptor concentrations increase during postnatal maturation of male guinea pigs

AU - Johnson, Allan E.

AU - Nock, Bruce

AU - Ryer, Helena

AU - Feder, Harvey

PY - 1984

Y1 - 1984

N2 - α1-Receptors were measured in intact male guinea pigs during the course of postnatal development. Receptor concentrations were significantly higher at day 1 in hypothalamus and at days 1 and 14 in preoptic area than at day 60. Conversely, in cerebral cortex, receptor concentrations were significantly lower in neonatal animals than in 60-day-old animals. There was no change in affinity of the receptor during development. Castration has no apparent effect on ai-receptor concentration in any brain area.

AB - α1-Receptors were measured in intact male guinea pigs during the course of postnatal development. Receptor concentrations were significantly higher at day 1 in hypothalamus and at days 1 and 14 in preoptic area than at day 60. Conversely, in cerebral cortex, receptor concentrations were significantly lower in neonatal animals than in 60-day-old animals. There was no change in affinity of the receptor during development. Castration has no apparent effect on ai-receptor concentration in any brain area.

KW - Adrenoceptors

KW - Androgen

KW - Hypothalamus

KW - Reproductive development

UR - http://www.scopus.com/inward/record.url?scp=0021337347&partnerID=8YFLogxK

U2 - 10.1159/000123898

DO - 10.1159/000123898

M3 - Article

C2 - 6325981

AN - SCOPUS:0021337347

SN - 0028-3835

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JO - Neuroendocrinology

JF - Neuroendocrinology

IS - 3

ER -

Hypothalamic and preoptic area α₁-receptor concentrations decrease, and cerebral cortical α₁-receptor concentrations increase during postnatal maturation of male guinea pigs

Abstract

Keywords

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