TY - JOUR
T1 - HYPOGONADISM, HYPERPROLACTINAEMIA, AND TEMPORAL LOBE EPILEPSY IN HYPOSEXUAL MEN
AU - Spark, Richard F.
AU - Wills, Carol A.
AU - Royal, Henry
N1 - Funding Information:
We thank Dr Edward Condon, Dr Howard Kolodny, Dr M. A. Charles, and Dr Bernard Robms, for helping us to acquire patient material for this study; and Ms Alice Striegel for secretarial assistance. This work was partly supported by a gift from Mr Ralph Covelli. M. B. is the recipient of Public Health Service Special Emphasis Research Career Award (1-KOlAM00589-01) from National Institute of Arthritis, Metabolism and Digestive Diseases and National Heart, Lung and Blood Institute. H. V. is the recipient of Research Scientist Development Award (1-KOI-AGO0148-01) from NIAMDD and National Institute of Aging. be addressed to M. B., Laboratory of Medical University, 1230 York Avenue, New York, NY
PY - 1984/2/25
Y1 - 1984/2/25
N2 - Previously unrecognised temporal lobe epilepsy (TLE) was diagnosed in 11 of 16 hyposexual men. 6 had neuroendocrine abnormalities (hypogonadism in 4 and hyperprolactinaemia in 2). 4 men with hypogonadism and TLE had persistently subnormal serum testosterone, with a blunted luteinising hormone (LH) response to luteinising hormone releasing hormone (LHRH) in 2 and, in these men, unlike those with isolated hypogonadism, there was no improvement in libido or potency when parenteral testosterone was given. Men with TLE and hyperprolactinaemia had normal serum testosterone and an enhanced serum LH response after LHRH, but effective doses of the dopaminergic agonists, bromocriptine or pergolide, did not produce sustained normoprolactinaemia. In the men with neuroendocrine dysfunction and TLE the most effective therapeutic sequence was first to treat the epilepsy with anticonvulsants and then to add appropriate neuroendocrine therapy. In 2 men hormone levels became normal and sexual function was restored on anticonvulsant therapy alone.
AB - Previously unrecognised temporal lobe epilepsy (TLE) was diagnosed in 11 of 16 hyposexual men. 6 had neuroendocrine abnormalities (hypogonadism in 4 and hyperprolactinaemia in 2). 4 men with hypogonadism and TLE had persistently subnormal serum testosterone, with a blunted luteinising hormone (LH) response to luteinising hormone releasing hormone (LHRH) in 2 and, in these men, unlike those with isolated hypogonadism, there was no improvement in libido or potency when parenteral testosterone was given. Men with TLE and hyperprolactinaemia had normal serum testosterone and an enhanced serum LH response after LHRH, but effective doses of the dopaminergic agonists, bromocriptine or pergolide, did not produce sustained normoprolactinaemia. In the men with neuroendocrine dysfunction and TLE the most effective therapeutic sequence was first to treat the epilepsy with anticonvulsants and then to add appropriate neuroendocrine therapy. In 2 men hormone levels became normal and sexual function was restored on anticonvulsant therapy alone.
UR - http://www.scopus.com/inward/record.url?scp=0021356586&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(84)91751-3
DO - 10.1016/S0140-6736(84)91751-3
M3 - Article
C2 - 6142149
AN - SCOPUS:0021356586
SN - 0140-6736
VL - 323
SP - 413
EP - 417
JO - The Lancet
JF - The Lancet
IS - 8374
ER -