TY - JOUR
T1 - Hypertensive left ventricular hypertrophy is associated with abnormal myocardial fatty acid metabolism and myocardial efficiency
AU - de las Fuentes, Lisa
AU - Soto, Pablo F.
AU - Cupps, Brian P.
AU - Pasque, Michael K.
AU - Herrero, Pilar
AU - Gropler, Robert J.
AU - Waggoner, Alan D.
AU - Dávila-Román, Victor G.
PY - 2006/6
Y1 - 2006/6
N2 - Background: Hypertension-induced left ventricular hypertrophy (LVH) is associated with an increased risk of cardiovascular morbidity and death by mechanisms not well characterized. Methods and Results: Myocardial fatty acid (FA) metabolism and left ventricular (LV) mass were evaluated in 13 patients with hypertensive LVH with normal LV ejection fraction and 42 normal control subjects (primary cohort). Contractile performance was also evaluated in 5 hypertensive LVH patients and 5 matched normal control subjects (magnetic resonance [MR] substudy). Myocardial FA utilization (MFAU) and myocardial FA oxidation (MFAO) were assessed by positron emission tomography by use of 1-carbon-11 palmitate. Myocardial contractile function (strain and stress) was determined by cardiac MR imaging with tissue tagging and calibrated arterial pressure traces; myocardial external minute work and efficiency were derived. In the primary cohort decreased MFAO was predictive of increased LV mass (model r2 = 0.61, P = .03). In the MR substudy decreased MFAO (corrected for myocardial oxygen consumption [MVO2]) in the hypertensive LVH group compared with the normal group (MFAU/MVO2, 26 ± 5 vs 37 ± 8; MFAO/MVO2, 24 ± 6 vs 35 ± 7; both P = .03) was paralleled by decreased myocardial external minute work (0.13 ± 0.03 J · g-1 · min-1 vs 0.17 ± 0.04 J · g-1 · min-1, P = .07) and decreased myocardial efficiency (5.2% ± 1.4% vs 7.1% ± 1.0%, P = .03). Conclusions: Abnormalities in myocardial FA metabolism are apparent in hypertensive LVH, and these abnormalities may be responsible, at least in part, for a reduction in myocardial efficiency.
AB - Background: Hypertension-induced left ventricular hypertrophy (LVH) is associated with an increased risk of cardiovascular morbidity and death by mechanisms not well characterized. Methods and Results: Myocardial fatty acid (FA) metabolism and left ventricular (LV) mass were evaluated in 13 patients with hypertensive LVH with normal LV ejection fraction and 42 normal control subjects (primary cohort). Contractile performance was also evaluated in 5 hypertensive LVH patients and 5 matched normal control subjects (magnetic resonance [MR] substudy). Myocardial FA utilization (MFAU) and myocardial FA oxidation (MFAO) were assessed by positron emission tomography by use of 1-carbon-11 palmitate. Myocardial contractile function (strain and stress) was determined by cardiac MR imaging with tissue tagging and calibrated arterial pressure traces; myocardial external minute work and efficiency were derived. In the primary cohort decreased MFAO was predictive of increased LV mass (model r2 = 0.61, P = .03). In the MR substudy decreased MFAO (corrected for myocardial oxygen consumption [MVO2]) in the hypertensive LVH group compared with the normal group (MFAU/MVO2, 26 ± 5 vs 37 ± 8; MFAO/MVO2, 24 ± 6 vs 35 ± 7; both P = .03) was paralleled by decreased myocardial external minute work (0.13 ± 0.03 J · g-1 · min-1 vs 0.17 ± 0.04 J · g-1 · min-1, P = .07) and decreased myocardial efficiency (5.2% ± 1.4% vs 7.1% ± 1.0%, P = .03). Conclusions: Abnormalities in myocardial FA metabolism are apparent in hypertensive LVH, and these abnormalities may be responsible, at least in part, for a reduction in myocardial efficiency.
KW - Hypertension-induced left ventricular hypertrophy
KW - myocardial efficiency
KW - myocardial fatty acid metabolism
UR - http://www.scopus.com/inward/record.url?scp=33646918913&partnerID=8YFLogxK
U2 - 10.1016/j.nuclcard.2006.01.021
DO - 10.1016/j.nuclcard.2006.01.021
M3 - Article
C2 - 16750782
AN - SCOPUS:33646918913
SN - 1071-3581
VL - 13
SP - 369
EP - 377
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 3
ER -