TY - JOUR
T1 - Hypersensitivity reaction to desipramine
AU - Panuska, James R.
AU - King, Thomas R.
AU - Korenblat, Phillip E.
AU - Wedner, H. James
PY - 1987/7
Y1 - 1987/7
N2 - Adverse reactions to the tricyclic antidepressant drugs imipramine and desipramine have been described and include eosinophilia, pulmonary infiltrates with eosinophilia, and elevated total serum IgE levels. The immunologic mechanism accounting for these adverse reactions has not been elucidated. This article describes a patient manifesting bronchospasm, profound eosinophilia, and elevated serum IgE levels after therapy with desipramine that resolved rapidly after withdrawal of the drug. Immunologic investigations failed to demonstrate specific IgE directed against a protein conjugate of desipramine but demonstrated the ability of desipramine to induce mast cell degranulation with direct intradermal skin challenges.
AB - Adverse reactions to the tricyclic antidepressant drugs imipramine and desipramine have been described and include eosinophilia, pulmonary infiltrates with eosinophilia, and elevated total serum IgE levels. The immunologic mechanism accounting for these adverse reactions has not been elucidated. This article describes a patient manifesting bronchospasm, profound eosinophilia, and elevated serum IgE levels after therapy with desipramine that resolved rapidly after withdrawal of the drug. Immunologic investigations failed to demonstrate specific IgE directed against a protein conjugate of desipramine but demonstrated the ability of desipramine to induce mast cell degranulation with direct intradermal skin challenges.
UR - http://www.scopus.com/inward/record.url?scp=0023184469&partnerID=8YFLogxK
U2 - 10.1016/S0091-6749(87)80185-9
DO - 10.1016/S0091-6749(87)80185-9
M3 - Article
C2 - 3598027
AN - SCOPUS:0023184469
SN - 0091-6749
VL - 80
SP - 18
EP - 23
JO - The Journal of Allergy and Clinical Immunology
JF - The Journal of Allergy and Clinical Immunology
IS - 1
ER -