Hyperpolarized 3He MRI of mouse lung

Joseph P. Dugas, Joel R. Garbow, Dale K. Kobayashi, Mark S. Conradi

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Hyperpolarized 3He images of mouse lung are presented. Ventilation images and measurements of 3He apparent diffusion coefficient (ADC) are reported in healthy mice, and preliminary studies of emphysema and lung cancer in mice are described using these techniques. The design and operation of an electronically controlled small-animal ventilator to deliver the hyperpolarized gas and control animal respiration are described. Images are acquired using an asymmetric gradient echo imaging method to enhance the signal-to-noise ratio of the rapidly diffusing 3He. In mice with elastase-induced emphysema, the whole-lung average ADC is greater by approximately 25%, a statistically significant difference, compared to healthy animals. By contrast, mice exposed to cigarette smoke for up to 12 months reveal no statistically relevant increases in ADC, although emphysema was not confirmed in these mice. A study of lung cancer (melanoma) in mice is also presented. While tumors are shown to cause substantial ventilation defects in the lung, these defects appear confined to the cancerous regions and do not extend to large-scale regions of the lung distal to the tumors.

Original languageEnglish
Pages (from-to)1310-1317
Number of pages8
JournalMagnetic resonance in medicine
Issue number6
StatePublished - Dec 2004


  • Diffusion
  • Emphysema
  • Hyperpolarized He
  • Hyperpolarized gas
  • Lung cancer
  • Lungs
  • MRI
  • Mouse
  • Ventilation


Dive into the research topics of 'Hyperpolarized 3He MRI of mouse lung'. Together they form a unique fingerprint.

Cite this