Hyperphosphatemia of chronic kidney disease

Keith A. Hruska, Suresh Mathew, Richard Lund, Ping Qiu, Raymond Pratt

Research output: Contribution to journalShort surveypeer-review

332 Scopus citations


Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. This review describes the pathobiology of hyperphosphatemia that develops as a consequence of positive phosphate balance in chronic kidney disease and the mechanisms by which hyperphosphatemia acts on neointimal vascular cells that are stimulated to mineralize in chronic kidney disease. The characterization of hyperphosphatemia of chronic kidney disease as a distinct syndrome in clinical medicine with unique disordered skeletal remodeling, heterotopic mineralization and cardiovascular morbidity is presented.

Original languageEnglish
Pages (from-to)148-157
Number of pages10
JournalKidney International
Issue number2
StatePublished - Jul 2008


  • CKD
  • Osteoblasts
  • Phosphate
  • Renal osteodystrophy
  • Vascular calcification
  • Vascular smooth muscle cells


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