TY - JOUR
T1 - Hyperinsulinism and Diabetes
T2 - Genetic Dissection of β Cell Metabolism-Excitation Coupling in Mice
AU - Remedi, Maria Sara
AU - Nichols, Colin G.
N1 - Funding Information:
Our own experimental work has been supported by National Institutes of Health Grant DK69445 (to C.G.N.). We are additionally grateful to the Washington University DRTC (DK20579) for reagent support.
PY - 2009/12/2
Y1 - 2009/12/2
N2 - The role of metabolism-excitation coupling in insulin secretion has long been apparent, but in recent years, in parallel with studies of human hyperinsulinism and diabetes, genetic manipulation of proteins involved in glucose transport, metabolism, and excitability in mice has brought the central importance of this pathway into sharp relief. We focus on these animal studies and how they provide important insights into not only metabolic and electrical regulation of insulin secretion, but also downstream consequences of alterations in this pathway and the etiology and treatment of insulin-secretion diseases in humans.
AB - The role of metabolism-excitation coupling in insulin secretion has long been apparent, but in recent years, in parallel with studies of human hyperinsulinism and diabetes, genetic manipulation of proteins involved in glucose transport, metabolism, and excitability in mice has brought the central importance of this pathway into sharp relief. We focus on these animal studies and how they provide important insights into not only metabolic and electrical regulation of insulin secretion, but also downstream consequences of alterations in this pathway and the etiology and treatment of insulin-secretion diseases in humans.
UR - http://www.scopus.com/inward/record.url?scp=70449864125&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2009.10.011
DO - 10.1016/j.cmet.2009.10.011
M3 - Review article
C2 - 19945402
AN - SCOPUS:70449864125
SN - 1550-4131
VL - 10
SP - 442
EP - 453
JO - Cell metabolism
JF - Cell metabolism
IS - 6
ER -