TY - JOUR
T1 - Hypercalcaemia of malignancy
T2 - a case of vitamin-D-mediated hypercalcaemia in lymphoma
AU - Mehta, Kanchi
AU - Awan, Maham
AU - Devlin, Shannon
AU - Jassal, Simerjot Kaur
N1 - Publisher Copyright:
© 2024 BMJ Publishing Group. All rights reserved.
PY - 2024/2/6
Y1 - 2024/2/6
N2 - Hypercalcaemia of malignancy (HCM) is a paraneoplastic syndrome that often portends a poor prognosis. We present an extremely rare (<1%) case of HCM due to extrarenal calcitriol (1,25-(OH)2D) production in a patient with splenic marginal zone lymphoma. A man in his 80s presented with a 3-week history of fatigue, unsteadiness and abdominal pain, and new findings of anaemia, kidney injury and hypercalcaemia. Laboratory evaluation, bone marrow biopsy and positron emission tomography/computed tomography (PET/CT) confirmed the diagnosis of splenic marginal zone lymphoma which produced calcitriol (1,25-(OH)2D3), causing the patient’s hypercalcaemia.
AB - Hypercalcaemia of malignancy (HCM) is a paraneoplastic syndrome that often portends a poor prognosis. We present an extremely rare (<1%) case of HCM due to extrarenal calcitriol (1,25-(OH)2D) production in a patient with splenic marginal zone lymphoma. A man in his 80s presented with a 3-week history of fatigue, unsteadiness and abdominal pain, and new findings of anaemia, kidney injury and hypercalcaemia. Laboratory evaluation, bone marrow biopsy and positron emission tomography/computed tomography (PET/CT) confirmed the diagnosis of splenic marginal zone lymphoma which produced calcitriol (1,25-(OH)2D3), causing the patient’s hypercalcaemia.
UR - http://www.scopus.com/inward/record.url?scp=85184828435&partnerID=8YFLogxK
U2 - 10.1136/bcr-2023-256126
DO - 10.1136/bcr-2023-256126
M3 - Article
C2 - 38320825
AN - SCOPUS:85184828435
SN - 1757-790X
VL - 17
JO - BMJ Case Reports
JF - BMJ Case Reports
IS - 2
M1 - e256126
ER -