Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression

Daisuke Kobayashi, Kazuhiro Kogawa, Kohsuke Imai, Toshio Tanaka, Akiko Sada, Shigeaki Nonoyama

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2 Scopus citations


Acute lymphoblastic leukemia with eosinophilia (ALLEo) is a rare but a distinctive clinical entity. Clinical features of idiopathic hyper-eosinophilic syndrome (HES) can be seen in patients with ALLEo. We report a 10-year-old girl, in whom HES was initially suspected but further investigation confirmed the diagnosis of acute B-cell lymphoblastic leukemia with myeloid antigen expression. Clinical response to chemotherapy was excellent with achievement of complete remission for 4 years. Serum interleukin-3 and -5 were elevated at presentation and normalized with disappearance of eosinophilia after induction therapy, supporting the reactive nature of eosinophilia in ALLEo. Hematologic malignancy should be considered in patients with hyper-eosinophilia, before attributing it to HES.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalPediatrics international : official journal of the Japan Pediatric Society
Issue number4
StatePublished - Aug 2012


  • acute lymphoblastic leukemia
  • eosinophilia
  • idiopathic hyper-eosinophilic syndrome
  • interleukin-3
  • interleukin-5
  • myeloid antigen


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