Hydrophobic anions potently and uncompetitively antagonize GABA _A receptor function in the absence of a conventional binding site

Keyphrases

• Binding Site 100%
• Receptor Function 100%
• GABAA Receptor (GABAAR) 100%
• Dipropylamine 100%
• Hydrophobic Anions 100%
• Antagonism 70%
• Voltage Dependence 30%
• Neurosteroids 30%
• Membrane Interaction 20%
• Tetraphenylborate 20%
• Neuronal Activity 10%
• Receptor Antagonist 10%
• Excitability 10%
• Structure-activity Relationship 10%
• Point mutation 10%
• Steady State 10%
• Transmembrane Domain 10%
• Receptor Antagonism 10%
• Competitive Antagonist 10%
• Xenopus Oocytes 10%
• Inhibitory Postsynaptic Current 10%
• Current Decay 10%
• Membrane-associated 10%
• Bovine Serum Albumin 10%
• Membrane Structure 10%
• Transmembrane Voltage 10%
• Hippocampal Neurons 10%
• Ion Channel Function 10%
• Voltage-gated Ion Channels 10%
• IC50 10%
• Current Amplitude 10%
• Capacitance 10%
• Voltage Clamp Technique 10%
• Key Binding 10%
• Pregnenolone Sulfate 10%
• Lock-and-key 10%
• GABA Concentration 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• 4 Aminobutyric Acid 100%
• Binding Site 100%
• Neurosteroid 42%
• Tetraphenylboron 28%
• Receptor Antagonist 14%
• Structure Activity Relationship 14%
• Xenopus 14%
• Ion Channel 14%
• Competitive Antagonist 14%
• IC50 14%
• Bovine Serum Albumin 14%
• Pregnenolone Sulfate 14%

Neuroscience

• Binding Site 100%
• GABAA Receptor 100%
• Neurosteroid 50%
• Neuronal Activity 16%
• Excitability 16%
• Receptor Antagonist 16%
• Gamma-Aminobutyric Acid 16%
• Point Mutation 16%
• Voltage-Gated Ion Channel 16%
• Bovine Serum Albumin 16%
• Membrane Leaflet 16%
• Pregnenolone Sulfate 16%
• Membrane Structure 16%
• Voltage Clamp 16%