Hydrochalarones: A novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast

Darren K. MacFarland, Kenneth L. Walker, Robert P. Lenk, Stephen R. Wilson, Krishan Kumar, Christopher L. Kepley, Joel R. Garbow

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.

Original languageEnglish
Pages (from-to)3681-3683
Number of pages3
JournalJournal of Medicinal Chemistry
Volume51
Issue number13
DOIs
StatePublished - Jul 10 2008

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