Hydrochalarones: A novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast

Darren K. MacFarland; Kenneth L. Walker; Robert P. Lenk; Stephen R. Wilson; Krishan Kumar; Christopher L. Kepley; Joel R. Garbow

doi:10.1021/jm800521j

Hydrochalarones: A novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast

Darren K. MacFarland, Kenneth L. Walker, Robert P. Lenk, Stephen R. Wilson, Krishan Kumar, Christopher L. Kepley, Joel R. Garbow

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.

Original language	English
Pages (from-to)	3681-3683
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	51
Issue number	13
DOIs	https://doi.org/10.1021/jm800521j
State	Published - Jul 10 2008

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abstract = "Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.",

author = "MacFarland, {Darren K.} and Walker, {Kenneth L.} and Lenk, {Robert P.} and Wilson, {Stephen R.} and Krishan Kumar and Kepley, {Christopher L.} and Garbow, {Joel R.}",

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T2 - A novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast

AU - MacFarland, Darren K.

AU - Walker, Kenneth L.

AU - Lenk, Robert P.

AU - Wilson, Stephen R.

AU - Kumar, Krishan

AU - Kepley, Christopher L.

AU - Garbow, Joel R.

PY - 2008/7/10

Y1 - 2008/7/10

N2 - Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.

AB - Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.

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U2 - 10.1021/jm800521j

DO - 10.1021/jm800521j

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JF - Journal of Medicinal Chemistry

IS - 13

ER -

Hydrochalarones: A novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast

Abstract

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